New Triterpene Aldehydes, Lucialdehydes A-C, from Ganoderma lucidum and Their Cytotoxicity against Murine and Human Tumor Cells
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概要
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Three new lanostante-type triterpene aldehydes, named lucialdehydes A-C (1-3), were isolated from the fruiting bodies of Ganoderma lucidum, together with ganodermanonol (4), ganodermadiol (5), ganodermanondiol (6), ganodermanontriol (7), ganoderic acid A (8), ganoderic acid B8 (9), and ganoderic acid C1 (10). The structures of the new triterpenes were determined as (24E)-3β-hydroxy-5α-lanosta-7,9(11),24-trien-26-al (1), (24E)-3,7-dioxo-5α-lanosta-8,24-dien-26-al (2), and (24E)-3β-hydroxy-7-oxo-5α-lanosta-8,24-dien-26-al (3), respectively, by spectroscopic means. The cytotoxicity of the compounds isolated from the ganoderma mushroom was tested in vitro against Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines. Lucialdehydes B, C (2, 3), ganodermanonol (4) and ganodermanondiol (6) showed cytotoxic effects on tested tumor cells. Of the compounds, lucialdehyde C (3) exhibited the most potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED_<50> values of 10.7, 4.7, 7.1, and 3.8 /μg/ml, respectively.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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NAKAMURA Norio
富山医科薬科大学和漢薬研究所
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Lee Hyeong-kyu
韓国
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Lee Hyeong-kyu
Korea Research Institute Of Bioscience And Biotechnology
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min B‐s
College Of Pharmacy Catholic University Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine University Of Toyama
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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GAO Jiang-Jing
Institute of Natural Medicine, University of Toyama
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MIN Byung-Sun
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Gao Jiang-jing
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Gao Jiang
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Gao Jiang
Institute Of Natural Medicine Facully Of Pharmaceutical Sciences And Pharmaceutical University
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Min Byung
College Of Pharmacy Catholic University Of Daegu
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Ahn Bun-mi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Ahn Eun-mi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universuty
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Lee Hyeong-kyu
Korea Res. Inst. Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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