Inhibitory Effects on HIV-1 Protease of Tri-p-coumaroylspermidine from Artemisia caruifolia and Related Amides
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概要
- 論文の詳細を見る
From a methanol extract of Artemisia caruifolia, which showed a moderate inhibitory activity on HIV-1 protease in a preliminary screening, N^1, N^5, N^<10>-tri-p-coumaroylspermidine and three dicaffeoylquinic acids were isolated. The former compound was found to appreciably inhibit HIV-1 protease. Of related amides which were chemically synthesized, N^1, N^5, N^<10> N^<14>-tetra-p-coumaroylspermine and N^1, N^4, N^7, N^<10> N^<13>-penta-p-coumaroyltetraethylenepentamine inhibited HIV-1 protease more potently than N^1, N^5, N^<10>-tri-p-conmaroylspermidine.
- 公益社団法人日本薬学会の論文
- 2001-07-01
著者
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Nakamura Norio
Institute Of Natural Medicine University Of Toyama
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Ma Chao-mei
Institute Of Natural Medicine University Of Toyama
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Hattori Masao
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Ma Caho-mei
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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