Inhibitory activities of Thai medicinal plants against herpes simplex type 1, poliovirus type 1, and measles virus
スポンサーリンク
概要
- 論文の詳細を見る
49種のタイ伝統薬物から作製した48のエタノールエキス,43の水エキスに対する抗ウイルス活性をプラーク減少法で検索した。本研究では,核酸やエンベロープ構造の異なるポリオウイルス1型,麻疹ウイルス,単純ヘルペスウイルス1型に対して検討を行なった。その結果ポリオウイルス1型に対しては52種,麻疹ウイルスには28種,単純ヘルペスウイルス1型には29種のエキスが阻害活性を示した。単純ヘルペス1型に有効であった29種の中では,Rhinacanthus nasutus(葉),Terminalia citrina(果実),Thevetia peruviana(葉)はエタノール,水の両エキスで阻害作用を示した。Derris scandens(葉),Plumbago indica(葉)およびCapsicum frutescens(果実)のエタノールエキスは単純ヘルペスウイルス1型にのみ活性があった。このことはポリオウイルスや麻疹ウイルスには無効で,単純ヘルペス1型のみに特異的に有効であることを示唆している。一方,26種のエキスはポリオウイルスあるいは麻疹ウイルス,また両方に有効であった。これらの結果はタイ伝統薬物からの29のエキスが抗ヘルペス剤として有力な候補となることを示している。
- 和漢医薬学会の論文
著者
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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TEWTRAKUL Supinya
Faculty of Pharmaceutical Sciences, Prince of Songkla University
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TEWTRAKUL Supinya
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Kurokawa M
School Of Medicine Toyama Medical And Pharmaceutical University
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Kurokawa Masahiko
Department Of Biochemistry School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Kurokawa Masahiko
Department Of Virology Facutly Of Medicine Toyama Medical And Pharmaceutical University
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SHIRAKI Kimiyasu
Departments of Virology, Toyama Medical and Pharmaceutical University
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Shiraki Kimiyasu
Department Of Virology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Tewtrakul Supinya
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kurimoto Masanori
Department Of Neurosurgery Toyama Medical And Pharmaceutical University
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Shiraki K
Department Of Virology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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AKANITAPICHAT Pannarat
Faculty of Pharmaceutical Sciences, Ubon Ratchathani University
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PRAMYOTHIN PORNPEN
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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SRIPANIDKULCHAI Bungorn
Faculty of Pharmaceutical Sciences, Khonkaen University
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Pramyothin Pornpen
タイ
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Pramyothin P
Chulalongkorn Univ. Bangkok Tha
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Akanitapichat Pannarat
Faculty Of Pharmaceutical Sciences Ubon Ratchathani University
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Sripanidkulchai Bungorn
Faculty Of Pharmaceutical Sciences Khonkaen University
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Sripanidkulchai Bungorn
Faculty Of Pharmaceutical Sciences Khon Kaen University
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