Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis
スポンサーリンク
概要
- 論文の詳細を見る
Seventeen thiopaeonimetabolin-I adducts were obtained as mixtures of diastereoisomers after incubation of paeoniflorin with Lactobacillius brevis in the presence of various thiols. The anticonvulsant activity of the adducts was investigated in mice using the maximal subcutaneous pentylenetetrazol seizure test and sodium valproate (1.5 mmol/kg) as a positive control. Thirteen adducts showed dose-dependent prolongation of latencies of clonic and tonic convulsions. Maximal protection against convulsions was effectively demonstrated by 8-(n-hexylthio)paeonimetabolin I (8) and 8-benzoylthiopaeonimetabolin I (18) at doses of 0.125 and 0.25 mmol/kg, respectively, while 100% protection was only achieved at 0.5 mmol/kg of 8-cyclopentylthiopaeonimetabolin I and 8-(p-tolylthio)paeonimetabolin I. The principal anticonvulsant activity of the diastereoisomers of 8 and 18 was attributed to their 7S-isomers [ED_<50> values of 0.09 and 0.12 mmol/kg, and protective indices of 5.0 and 4.0 for 8(7S) and 18 (7S), respectively], while the 7R counterparts [8 (7R) and 18 (7R)] showed a muscle relaxation effect.
- 社団法人日本薬学会の論文
- 1999-05-15
著者
-
Watanabe Hiroshi
Institute for Chemical Research, Kyoto University
-
MESELHY Meselhy
Institute of Natural Medicine, Faculty of Pharmaceutical Sciences and Pharmaceutical University
-
Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
-
Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
-
Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
-
Nakamura Norio
Institute Of Natural Medicine University Of Toyama
-
HATTORI Masao
Institute of Natural Medicine, University of Toyama
-
Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
-
Murakami Yuko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
-
ABDEL-HAFEZ Atef
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
-
Mohamed Tarek
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
-
EL-GENDY Mahmound
Department of Pharmaceutical Medical Chemistry, Faculty of Pharmacy, Assiut University
-
MAHFOUZ Nadia
Department of Pharmaceutical Medical Chemistry, Faculty of Pharmacy, Assiut University
-
ABDEL-HAFEZ Atef
Faculty of Pharmacy, Assiut University
-
MURAKAMI Yukihisa
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
-
EL-GENDY Mahmoud
Faculty of Pharmacy, Assiut University
-
MAHFOUZ Nadia
Faculty of Pharmacy, Assiut University
-
MOHAMED Tarek
Faculty of Pharmacy, Assiut University
-
Abdel-hafez Atef
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
Meselhy M
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
-
Meselhy Meselhy
Faculty Of Pharmacy Cairo University
-
Meselhy Meselhy
(present Address)faculty Of Pharmacy Cairo University
-
El-gendy Mahmound
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
-
Watanabe H
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
-
Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
-
Meselhy Meselhy
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences And Pharmaceutical University
-
Mahfouz Nadia
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
-
Murakami Y
Toho Univ. Chiba Jpn
-
Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
-
Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
-
Nakamura Norio
Institute Of Natural Medicine
-
Watanabe Hiroshi
Institute For Chemical Research Kyoto University
関連論文
- Enhanced expression of BCL2/adenovirus EIB 19-kDa-interacting protein 3 mRNA, a candidate for intrinsic depression-related factor, and effects of imipramine in the frontal cortex of stressed mice
- Rheological and Dielectric Behavior of Polyisoprene under Pressurized Carbon Dioxide
- Effects of Manganese Complexes of Curcumin and Diacetylcurcumin on Kainic Acid-Induced Neurotoxic Responses in the Rat Hippocampus(Pharmacology)
- Hypouricemic Effects of Acacetin and 4,5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats(Pharmacology)
- Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants(Pharmacognosy)
- Fischer Indolization and Its Related Compounds. XIX. Syntheses of Ethyl 4-Methoxy- and Ethyl 5-Methoxy-1-phenyl-3H-benz [e] indole-2-carboxylates
- Human intestinal Bacteroides spp. RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats
- Enhanced Expression of BCL2/Adenovirus EIB 19-kDa-Interacting Protein 3 mRNA, a Candidate for Intrinsic Depression-Related Factor, and Effects of Imipramine in the Frontal Cortex of Stressed Mice
- Effects of Choto-san and Its Related Constituents on Endogenous Antioxidant Systems(Pharmacology)
- Antioxidant and Free Radical-Scavenging Activity of Choto-san and Its Related Constituents(Pharmacology)
- Fischer Indolization of Variously ortho-Substituted Phenylhydrazones (Fischer Indolization and Its Related Compounds. XXV)
- A NEW SYNTHESIS OF EUPOLAURAMINE FROM A BENZ [f] INDOLE DERIVATIVE
- Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum
- Pharmacokinetic study of benzoylmesaconine in rats using an enzyme immunoassay system
- Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacterium acnes and Lipopolysaccharide Induced Hepatic Injury in Mice
- Quantitative Determination of Bitter Principles in Specimens of Ganoderma lucidum Using High-Performance Liquid Chromatography and Its Application to the Evaluation of Ganoderma Products
- Viscoelastic Mode Distribution of Moderately Entangled Linear Polymers
- Investigation on traditional medicine in Myanmar and Vietnam
- Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease
- Enantioselective Dehydroxylation of Enterodiol and Enterolactone Precursors by Human Intestinal Bacteria(Pharmacognosy)
- Inhibition of Cytopathic Effect of Human Immunodeficiency Virus Type-1 by Various Phorbol Derivatives
- The Heterocyclic Ring Fission and Dehydroxylation of Catechins and Related Compounds by Eubacterium sp.Strain SDG-2, a Human Intestinal Bacterium
- Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum
- Effects of Mitragynine on cAMP Formation Mediated by δ-Opiate Receptors in NG108-15 Cells
- Viscoelastic Properties of Poly(vinyl chloride) Gels : Effect of Plasticizer Type
- Dielectric Behavior of PVC Gels and Sols in Dioctyl Phthalate
- New Paeonilactone-A Adducts Formed by Anaerobic Incubation of Paeoniflorin with Lactobacillus brevis in the Presence of Arylthiols
- Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis
- Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship
- Primitive chain network simulations of conformational relaxation for individual molecules in the entangled state (2) Retraction from stretched states (計算機レオロジー特集号)
- Primitive Chain Network Simulations of Conformational Relaxation for Individual Molecules in the Entangled State
- Primitive Chain Network Simulations on Dielectric Relaxation of Linear Polymers under Shear Flow
- Synthetic Studies of Indoles and Related Compounds. XXVII. A New Synthesis of Crenatine from Ethyl Indole-2-carboxylate
- Fischer Indolization and Its Related Compounds. XVIII. Formation of Four Unexpected Angular Benz [e] indoles on Fischer Indolization of Ethyl Phenylpyruvate 2-[(1,4-Dimethoxy-2-naphthyl) hydrazone]
- Synthetic Studies on Indoles and Related Compounds. XXVI. The Debenzylation of Protected Indole Nitrogen with Aluminum Chloride. (2)
- Permanent Occlusion of Bilateral Internal Carotid Arteries Produces Cognitive Deficits in Two Learning Behavior Tasks
- Conversion of aconitine lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice
- Four Mono-tetrahydrofuran Ring Acetogenins, Montanacins B-E, from Annona montana
- 12-O-Acetylphorbol-13-decanoate Potently Inhibits Cytopathic Effects of Human Immunodeficiency Virus Type 1 (HIV-1), without Activation of Protein Kinase C
- Apparatus for Small-Angle Neutron Scattering and Rheological Measurements under Sheared Conditions
- Possible Involvement of Signal Transducers and Activators of Transcription 3 System on Depression in the Model Mice Brain
- Chotosan Enhances Macrophage Colony-Stimulating Factor mRNA Expression in the Ischemic Rat Brain and C6Bu-1 Glioma Cells(Biochemistry)
- Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice
- Preventive Effect of Chotosan, a Kampo Medicine, on Transient Ischemia-Induced Learning Deficit Is Mediated by Stimulation of Muscarinic M_1 But Not Nicotinic Receptor(Pharmacology)
- Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin(Pharmacology)
- The Effects of Choto-san on the mRNA Expression of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative(Pharmacology)
- Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures : Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression(Pharmacology)
- Cytoprotective and Cytotoxic Effects of Curcumin : Dual Action on H_2O_2-Induced Oxidative Cell Damage in NG108-15 Cells
- Protective effect of Choto-san and its related constituents on hydrogen peroxide-induced cell damage in NG108-15 cells
- Ameliorative Effects of Paeoniflorin, a Major Constituent of Peony Root, on Adenosine A_1 Receptor-Mediated Impairment of Passive Avoidance Performance and Long-Term Potentiation in the Hippocampus
- GTS-21, a Nicotinic Agonist, Attenuates Multiple Infarctions and Cognitive Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
- Chronic Cerebral Hypoperfusion-Induced Neuropathological Changes in Rats
- Tacrine Improves Working Memory Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
- Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats
- Multiple Representation of Linear Dielectric Response
- Wild Ginseng Grows in Myanmar
- A Wild-type Japanese Measles Virus Strain Inducing Predominant Early Down-regulation of CD46
- Molecular Cloning of a Complementary DNA for a Membrane Cofactor Protein (MCP, CD46)/Measles Virus Receptor on Vero Cells and Its Functional Characterization
- Metabolism and pharmacokinetics of paeoniflorin, a bioactive component from Peony roots
- Non-Equilibrium Relaxation Analysis on Two-Dimensional Melting(The 50th Anniversary of the Alder Transition -Recent Progress on Computational Statistical Physics-)
- Fischer Indolization and Its Related Compounds. XXIV. Fischer Indolization of Ethyl Pyruvate 2-(2-Methoxyphenyl)phenylhydrazone
- Fischer Indolization and Its Related Compounds. XXIII. Fischer Indolization of Ethyl Pyruvate 2-(2,6-Dimethoxyphenyl)phenylhydrazone
- Synthesis of Decalin Type Chiral Synthons Base on Enzymatic Function
- Biotransformation of a C-Glycosylflavone, Abrusin 2"-O-β-D-Apioside, by Human Intestinal Bacteria
- Nonlocal Unitary Transformation and Haldane State in S=1/2 Antiferromagnetic Ladder Model
- Human Intestinal Bacteria Capable of Transforming Secoisolariciresinol Diglucoside to Mammalian Lignans, Enterodiol and Enterolactone
- Positron Lifetime in C_/C_ Powder
- Facilitatory and Inhibitory Effects of Harmaline on the Tryptophan- Induced 5-Hydroxytryptamine Syndrome and Body Temperature Changes in Pargyline-Pretreated Rats
- Rheo-SANS Study of an Aqueous Suspension of Poly(Methyl Methacrylate-co-Styrene) Particle
- Rheology of Aqueous Suspensions of Polystyrene Particles with Bimodal Radius Distribution
- Kinetics of Living Anionic Polymerization of Polystyrenyl Lithium in Cyclohexane
- γ-Herpesviruses and cellular signaling in AIDS-associated malignancies
- Effect of Herbimycin A on Tyrosine Kinase Receptors and Platelet Derived Growth Factor (PDGF)-Induced Signal Transduction
- Chain Relaxation Time in ABS Polymer Melts
- Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats
- Highly Isotactic Poly(vinyl alcohol) Derived from tert-Butyl Vinyl Ether V. Viscoelastic Behavior of Highly Isotactic Poly(vinyl alcohol) Films
- A Study for Palladium-catalyzed Chemoselective Vinylation at C-3 Position of 4-Bromo-1-tosylindole
- Substituent Effects in the Fischer Indolization of (2-Sulfonyloxyphenyl)-hydrazones (Fischer Indolization and Related Compounds . XXX)
- Kinetics of Anionic Polymerization of Polybutadienyl Lithium in Benzene : An Osmotic Effect on Propagation Process
- Neuropharmacological Actions of Pluchea indica LESS Root Extract in Socially Isolated Mice
- β-Acylation of Ethyl Pyrrole-2-carboxylate by Friedel-Crafts Acylation : Scope and Limitations (Synthetic Studies on Indoles and Related Compounds. XXXVIII)
- New Strategy for Indole Synthesis from Ethyl Pyrrole-2-carboxylate (Synthetic Studies on Indoles and Related Compounds. XXXIX)
- Viscoelastic Behavior of Scarcely Crosslinked Poly(dimethyl siloxane) Gels: 2. Effects of Sol Component and Network Strand Length
- A Note for Kohlrausch-Williams-Watts Relaxation Function
- Thermal, Structural, and Viscoelastic Characterization of cis-Poly(phenylene vinylene) Related to its Photo-Isomerization
- Stress Overshoot in Shear Flow of an Entangled Polymer with Bimodal Molecular Weight Distribution
- 2-Chloro-N, N-dibenzoylaniline : a Selective N-Benzoylating Reagent
- Efficient Implementations of Molecular Dynamics Simulations for Lennard-Jones Systems(General and Mathematical Physics)
- Dynamics of Monofunctional Polybutadienyl Lithium Chains Aggregated in Benzene
- Viscoelastic Behavior of Scarcely Crosslinked Poly(dimethyl siloxane) Gel : 3. Examination of Gelation Process
- Nonlinear Mechanical Behavior of Scarcely Crosslinked Poly(dimethyl siloxane) Gel : Effect of Strand Length Polydispersity
- Viscoelastic Behavior of Scarcely Crosslinked Poly(dimethyl siloxane) Gel
- Primitive Chain Network Simulations on Dielectric Relaxation of Linear Polymers under Shear Flow
- Rheo-SANS Study of an Aqueous Suspension of Poly (Methyl Methacrylate-co-Styrene) Particle
- Rheology of Aqueous Suspensions of Polystyrene Particles with Bimodal Radius Distribution
- Effects of Self-efficacy on Adjustment to College
- Dynamic Tube Dilation in Branched Polymers(Non Equilibrium Soft Matter)
- Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures : Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression
- Rheology of Aqueous Solution of Hydrophobically Modified Ethoxylated Urethane (HEUR) with Fluorescent Probes at Chain Ends : Thinning Mechanism