Inhibitory Effects of Triterpene-Azidothymidine Conjugates on Proliferation of Human Immunodeficiency Virus Type 1 and Its Protease
スポンサーリンク
概要
- 論文の詳細を見る
The conjugates of some dicarboxylic acid hemiesters of triterpenes which show potent inhibition against human immunodeficiency virus type 1 protease (HIV-1 PR) with a reverse transcriptase inhibitor azidothymidine (AZT) or anti-HIV alkaloid FK 3000 were prepared, and their inhibitory activities were investigated against HIV-induced cytopathic effects (CPE) and HIV-l PR. Most of the triterpene-AZT conjugates showed potent anti-HIV activity as well as moderate to potent PR inhibitory activity, though AZT itself showed no PR inhibitory activity at all. However, the triterpene-FK 3000 conjugates showed neither PR inhibitory activity nor anti-HIV activity.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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NAKAMURA Norio
富山医科薬科大学和漢薬研究所
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Nakamura Norio
Institute Of Natural Medicine University Of Toyama
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MA Chao-Mei
Institute of Natural Medicine, University of Toyama
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Ma Chao-mei
富山大学和漢医薬学総合研究所
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Otake Toru
Osaka Prefectural Institute Of Public Health
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Otake Toru
Showa Denko K.k.
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Ma Chao-mei
Institute Of Natural Medicine University Of Toyama
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KAWAHATA Takuya
Osaka Prefectural Institute of Public Health
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Ohi Tetsuo
Botanical Gardens Graduate School Of Sciences The University Of Tokyo
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Kawahata T
Division Of Virology Department Of Infectious Diseases Osaka Prefectural Institute Of Public Health
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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