Human Intestinal Bacterium, Strain END-2 Is Responsible for Demethylation as Well as Lactonization during Plant Lignan Metabolism
スポンサーリンク
概要
- 論文の詳細を見る
A human intestinal bacterium, strain END-2, which enantioselectively oxidizes (+)-enterodiol (END) to (+)-enterolactone (ENL) through enterolactol is also responsible for demethylation during plant lignan metabolism. A free hydroxyl group adjacent to the methoxy group is required for demethylation. The bacterium transformed (+)- and (−)-secoisolariciresinol to (+)-ENL and (−)-END, respectively, by co-incubation with strain ARC-1, which is responsible for dehydroxylation.
- 公益社団法人 日本薬学会の論文
著者
-
HATTORI Masao
Institute of Natural Medicine, University of Toyama
-
Jin Jong-Sik
Institute of Natural Medicine, University of Toyama
-
Jin Jong-sik
Institute Of Natural Medicine University Of Toyama
-
Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
関連論文
- Effects of Tokishakuyakusan on the ovary in hypophysectomized rats
- Estrogenic and Antiestrogenic Activities of Phloridzin
- Effects of Tokishakuyakusan on hypothalamic pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP type I receptor (PAC_1) expression in hypophysectomized and ovariectomized rats
- Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum
- Pharmacokinetic study of benzoylmesaconine in rats using an enzyme immunoassay system
- Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacterium acnes and Lipopolysaccharide Induced Hepatic Injury in Mice
- Quantitative Determination of Bitter Principles in Specimens of Ganoderma lucidum Using High-Performance Liquid Chromatography and Its Application to the Evaluation of Ganoderma Products
- The C-Glucosyl Bond of Puerarin Was Cleaved Hydrolytically by a Human Intestinal Bacterium Strain PUE to Yield Its Aglycone Daidzein and an Intact Glucose
- Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease
- Enantioselective Dehydroxylation of Enterodiol and Enterolactone Precursors by Human Intestinal Bacteria(Pharmacognosy)
- Developing of anti-HIV agents from natural resources(Chemical & Pharmacological study)
- Sesquiterpenes and Alkaloids from Lindera chunii and Their Inhibitory Activities against HIV-1 Integrase
- Inhibition of Cytopathic Effect of Human Immunodeficiency Virus Type-1 by Various Phorbol Derivatives
- Inhibitory effects of flavonoids on human immunodeficiency virus type-I integrase
- The Heterocyclic Ring Fission and Dehydroxylation of Catechins and Related Compounds by Eubacterium sp.Strain SDG-2, a Human Intestinal Bacterium
- Triterpenes from the Spores of Ganoderma lucidum and Their Cytotoxicity against Meth-A and LLC Tumor Cells
- Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activites by Constituents of Juglans mandshurica
- Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum
- Medicinal Foodstuffs. XXIV.^ Chemical Constituents of the Processed Leaves of Apocynum venetum L. : Absolute Stereostructures of Apocynosides I and II
- Biotransformation of C-Glucosylisoflavone Puerarin to Estrogenic (3S)-Equol in Co-culture of Two Human Intestinal Bacteria(Pharmacognosy)
- Estrogenic Effects of a Kampo Formula, Tokishakuyakman, in Parous Ovariectomized Rats(Pharmacology)
- New Lanostane Triterpene Lactones from the Vietnamese Mushroom Ganoderma colossum (FR.) C. F. BAKER
- Enantioselective Oxidation of Enterodiol to Enterolactone by Human Intestinal Bacteria(Pharmacognosy)
- Estrogenic and Anti-estrogenic Activities of Cassia tora Phenolic Constituents
- Anti-estrogenic Activity of Mansorins and Mansonones from the Heartwood of Mansonia gagei DRUMM.
- Isolation and Characterization of a Human Intestinal Bacterium, Eubacterium sp. ARC-2, Capable of Demethylating Arctigenin, in the Essential Metabolic Process to Enterolactone(Pharmacology)
- Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
- In vivo antitumor effects of bitter principles from the antlered form of fruiting bodies of Ganoderma lucidum
- Antiviral Activity of the Marine Alga Symphyocladia latiuscula against Herpes Simplex Virus (HSV-1) in Vitro and Its Therapeutic Efficacy against HSV-1 Infection in Mice(Pharmacognosy)
- Two Proteins, Mn^, and Low Molecular Cofactor Are Required for C-Glucosyl-Cleavage of Mangiferin(Biochemistry)
- Isolation of a Human Intestinal Bacterium That Transforms Mangiferin to Norathyriol and Inducibility of the Enzyme That Cleaves a C-Glucosyl Bond(Pharmacognosy)
- Constituents of the seeds of Glycyrrhiza uralensis
- Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
- 28E-03 Laxative Effect of Rhein Induced by Bacteroides sp. RHEIN, a Human Intestinal Bacterium
- 薬物代謝工学分野(資源開発部門,各部門・附属センターの活動と業績)
- New Paeonilactone-A Adducts Formed by Anaerobic Incubation of Paeoniflorin with Lactobacillus brevis in the Presence of Arylthiols
- Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis
- Quantitative determination of maleic and succinic acid derivatives in the mycelium of Antrodia cinnamomea
- 和漢薬研究所の過去、現在、そして将来
- 研究所年報 巻頭の言葉
- Four Mono-tetrahydrofuran Ring Acetogenins, Montanacins B-E, from Annona montana
- 12-O-Acetylphorbol-13-decanoate Potently Inhibits Cytopathic Effects of Human Immunodeficiency Virus Type 1 (HIV-1), without Activation of Protein Kinase C
- Biotransformation of Pinoresinol Diglucoside to Mammalian Lignans by Human Intestinal Microflora, and lsolation of Enterococcus faecalis Strain PDG-1 Responsible for the Transformation of(+)-Pinoresinol to(+)-Lariciresinol
- Transformation of Arctiin to Estrogenic and Antiestrogenic Substances by Human Intestinal Bacteria
- Anti-human Immunodeficiency Virus-1 Protease Activity of New Lanostane-Type Triterpenoids from Ganoderma sinense
- Apocynins A-D : New Phenylpropanoid-substituted Flavan-3-ols Isolated from Leaves of Apocynum venetum (Luobuma-Ye)
- Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury
- Tinospora tuberculata Suppresses Nitric Oxide Synthesis in Mouse Macrophages
- Transformation of Ergosterol Peroxide to Cytotoxic Substances by Rat Intestinal Bacteria(Biopharmacy)
- Three New Triterpene Saponins from the Seeds of Aesculus chinensis
- Triterpenes from Cynomorium songaricium-analysis of HCV protease inhibitory activity, quantification, and content change under the influence of heating
- Amino acids and phosphates stimulate hatching of Ochlerotatus koreicoides (Diptera : Culicidae) eggs
- Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica
- New Triterpene Aldehydes, Lucialdehydes A-C, from Ganoderma lucidum and Their Cytotoxicity against Murine and Human Tumor Cells
- Biotransformation of a C-Glycosylflavone, Abrusin 2"-O-β-D-Apioside, by Human Intestinal Bacteria
- Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum
- Kaempferol Acetylrhamnosides from the Rhizome of Dryopteris crassirhizoma and Their Inhibitory Effects on Three Different Activities of Human Immunodeficiency Virus-1 Reverse Transcriptase
- Triterpenes and Lignans from Artemisia caruifolia and Their Cytotoxic Effects on Meth-A and LLC Tumor Cell Lines
- Inhibitory effect of Tibetan medicinal plants on viral polymerases
- Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells
- Inhibitory Effects of Triterpene-Azidothymidine Conjugates on Proliferation of Human Immunodeficiency Virus Type 1 and Its Protease
- Biotransformation of Phorbol by Human Intestinal Bacteria
- Antioxidative Activities of Galloyl Glucopyranosides from the Stem-Bark of Juglans mandshurica
- Estrogenic and Antiestrogenic Activities of the Roots of Moghania philippinensis and Their Constituents (Pharmacognosy)
- Human Intestinal Bacteria Capable of Transforming Secoisolariciresinol Diglucoside to Mammalian Lignans, Enterodiol and Enterolactone
- Study on the Components of Luobuma with Peroxynitrite-Scavenging Activity
- Confirmation that Luobuma ameliorates the deterioration of antioxidant defense in senescence-accelerated mice
- Inhibitory Effects on HIV-1 Protease of Tri-p-coumaroylspermidine from Artemisia caruifolia and Related Amides
- Hepatoprotective Effects of Palauan Medical Plants(The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
- Absolute Configuration of Cipadesin and Febrifugin from the Seeds of Cipadessa baccifera
- Chemical Modification of Oleanene Type Triterpenes and Their Inhibitory Activity against HIV-1 Protease Dimerization
- Four New Saponins from the Root Bark of Aralia elata
- Inhibitory activities of Thai medicinal plants against herpes simplex type 1, poliovirus type 1, and measles virus
- Antioxidative Activities of Galloyl Glucopyranosides from the Stem-Bark of Juglans mandshurica
- Human Intestinal Bacterium, Strain END-2 Is Responsible for Demethylation as Well as Lactonization during Plant Lignan Metabolism
- 偶然からモノを見つけだす能力を生かす : 腸内細菌による和漢薬の代謝研究を振り返って
- Constituents of the seeds of Glycyrrhiza uralensis
- Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
- Absolute Configuration of Cipadesin and Febrifugin from the Seeds of Cipadessa baccifera(Natural Medicine Note)
- Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons
- Isolation and Characterization of a Human Intestinal Bacterium Eggerthella sp. CAT-1 Capable of Cleaving the C-Ring of (+)-Catechin and (−)-Epicatechin, Followed by p-Dehydroxylation of the B-Ring
- Enzymatic Cleavage of the C-Glucosidic Bond of Puerarin by Three Proteins, Mn2+, and Oxidized Form of Nicotinamide Adenine Dinucleotide
- Baicalein 6-O-β-d-Glucopyranuronoside Is a Main Metabolite in the Plasma after Oral Administration of Baicalin, a Flavone Glucuronide of Scutellariae Radix, to Rats