Sesquiterpenes and Alkaloids from Lindera chunii and Their Inhibitory Activities against HIV-1 Integrase

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概要

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• Three new eudesmane type sesquiterpenoid lindenanolides E (1), F (2) and G (3), and two new aporphine alkaloid lindechunines A (18) and B (20) were isolated from roots of Lindera chunil MERR., together with seven known sesquiterpenes including a new naturally-occurring lindenanolide H (4) and eight known aporphine alkaloids. The structures of these compounds were determined by spectroscopic means. Of the isolated compounds, hernandonine (14), laurolistine (16), 7-oxohernangerine (17) and lindechunine A (18) showed significant antihuman immunodeficiency virus type I (HIV-1) integrase activity with IC_<50> values of 16.3, 7.7, 18.2 and 21.1μM, respectively. The major alkaloids presented in the roots of L. chunii were quantitatively analyzed by an HPLC method.

• 社団法人日本薬学会の論文
• 2002-09-01

著者

• NAKAMURA Norio

  富山医科薬科大学和漢薬研究所

• 花岡 美代次

  金沢大学薬学部

• Nakamura Norio

  Institute Of Natural Medicine University Of Toyama

• HATTORI Masao

  Institute of Natural Medicine, University of Toyama

• Wang Z‐t

  Department Of Pharmacognosy China Pharmaceutical University

• Zhang Chao-feng

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University:department Of Medical Pla

• Hattori Masao

  Institute Of Natural Medicine University Of Toyama

• TEWTRAKUL Supinya

  Faculty of Pharmaceutical Sciences, Prince of Songkla University

• TEWTRAKUL Supinya

  Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

• SUN Qi-shi

  Department of Medical Plant, Shenyang Pharmaceutical University

• WANG Zheng-tao

  Department of Pharmacognosy, China Pharmaceutical University

• FUJIWARA Tamio

  Shionogi Institute for Medical Science

• FUJIWARA Tamio

  b Shionogi Institute for Medical Science

• Fujiwara T

  B Shionogi Institute For Medical Science

• Sun Qi-shi

  Department Of Medical Plant Shenyang Pharmaceutical University

• Nakamura N

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Tewtrakul Supinya

  Faculty Of Pharmaceutical Sciences Prince Of Songkla University

• Tewtrakul Supinya

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Wang Zheng-tao

  Department Of Pharmacognosy China Pharmaceutical University

• Hattori Masao

  Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences

• Hattori Masao

  Metabolic Engineering Institute Of Natural Medicine University Of Toyama

• Nakamura Norio

  Institute Of Natural Medicine Toyama And Pharmaceutical University

• Nakamura Norio

  Institute Of Natural Medicine

• 花岡 美代次

  Institute Of Natural Medicine University Of Toyama

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