Studies on 1-Azabicyclo Compounds. XXIV. Synthesis and Stereochemistry of 10-Ethyl-, 10-Vinyl-, and 10-Ethynyl-quinolizidine Methiodides
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概要
- 論文の詳細を見る
On quaternization of 10-ethyl-, 10-vinyl-, and 10-ethynyl-quinolizidine with methyl iodide, the formation of the cis methiodide vs. the corresponding trans methiodide increased according to the order of the bulkiness of the 10-substituent as CH_3CH_2>CH_2=CH>CH=C. The stereochemistry of the above methiodides was established. The N^+-methyl signals of the cis 10-substituted quinolizidine methiodides were confirmed to appear at higher field than those of the corresponding trans methiodides except for the 10-ethynyl methiodides in their nuclear magnetic resonance spectra.
- 社団法人日本薬学会の論文
- 1975-05-25
著者
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荒田 義雄
Faculty Of Pharmaceutical Sciences Kanazawa University
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花岡 美代次
Faculty of Pharmaceutical Sciences, Kanazawa University
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花岡 美代次
金沢大学薬学部
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花岡 美代次
Faculty Of Pharmaceutical Sciences Osaka University
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花岡 美代次
Faculty Of Pharmaceutical Sciences Kanazawa University
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金 申圭
Faculty of Pharmaceutical Sciences, Kanazawa University
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金 申圭
College Of Pharmacy Kyung Hee University
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