Studies on 1-Azabicyclo Compounds. XVII. Transannular Reaction of cis- and trans-1,2,3,4,7,8,9,10-Octahydroazecine and Their Derivatives

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概要

• 論文の詳細を見る

• 1-Methyl- and 1-ethyl-cis-octahydroazecine (I and X) were synthesized stereoselectively. Transannular reaction of the trans-N-oxide (VII) leading to decahydro-1-methylazecin-6-one (XI) proceeded more smoothly than that of the cis-N-oxide (VI). However, transannular cyclization between the nitrogen and the double bond of N-acetyl-and N-ethoxycarbonyl-cis-octahydroazecine (VIII and XII) producing 1-azabicyclodecane (XVI) proceeded much more easily than that of the corresponding trans derivatives (IX and XIII).

• 公益社団法人日本薬学会の論文
• 1973-12-25

著者

• 荒田 義雄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 安田 信吾

  金沢大・薬

• 安田 信吾

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 小田 幸雄

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 小田 幸雄

  Faculty Of Pharmaceutical Sciences Kanazawa University

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