Studies on 1-Azabicyclo Compounds. XI. Syntheses of Ten-membered Ring Amine Derivatives from Di (10-octahydroquinolizinyl)-hydroxylamine

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概要

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• Reaction of di (10-octahydroquinolizinyl) hydroxylamine (I) with methyl iodide in methanol gave 6-hydroxyimino-1-methyldecahydroazecine methiodide (II), 5-methyl-10-methoxyoctahydroquinolizinium iodide (III) and 3,4,6,7,8,9-hexahydro-2H-qunolizine (IV). Reduction of II with lithium in liquid ammonia afforded 6-hydroxyimino-1-methyldecahydroazecine (X), 6-amino-1-methyloctahydroazecine (XI) and IV. In addition, the similar reduction of III led to the formation of IV, VIII and cis-1-methyl-1,2,3,4,7,8,9,10-octahydroazecine (XIV).

• 公益社団法人日本薬学会の論文
• 1972-04-25

著者

• 荒田 義雄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 塩田 登美子

  金沢大学薬学部

• 塩田 登美子

  Faculty of Pharmaceutical Sciences, Kanazawa University

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