Constituents of Rhizoma nupharis. XXII. Structure of Nuphamine

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概要

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• A new alkaloid (I), C_<15>H_<23>O_<2>N has been isolated from Nuphar japonicum DC. and named nuphamine. The compound (III) obtained by the catalytic reduction after the chlorination of I with thionyl chloride is completely in accordance with (-)-desoxynupharamine, derived from nupharamine (IX). By the catalytic reduction of I with palladium-carbon, dihydronuphamine (V), (-)-deoxynupharidine (VI-A) and allodeoxynupharidine (VI-B) were prepared. VI-A and VI-B were also prepared from V. Judging from these reactions and the nuclear magnetic resonance spectra, the structure of I has been determined to be presented by the fromula VIII. The steric chemical correlations among the alkaloids, (-)-desoxynupharidine (VI-A), (-)-nuphamine (VIII) and (-)-nupharamine (IX) isolated from Nuphar iaponicum have been also achieved.

• 公益社団法人日本薬学会の論文
• 1965-10-25

著者

• 荒田 義雄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 大橋 力

  Faculty of Pharmaceutical Sciences, Kanazawa University

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