Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells

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概要

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• The effect of the root of Salvia miltiorrhiza (SM) on angiotensin II (Ang II)-induced hypertrophic responses was examined in cultured neonatal rat cardiac cells (cardiomyocytes and non-cardiomyocytes). The methanol eluate fraction (SM2) of the water extract and the ethyl acetate-insoluble fraction (SM3) and its soluble fraction (SM4) partitioned from the methanol extract were prepared. Treatment with SM4 (5 – 80 μg/ml), not SM2 and SM3, for 24 h produced dose-dependent cytotoxicity against cardiac cells relative to the reduction in viability and the morphological injury of cardiomyocytes. SM2 or SM3 in the absence of Ang II affected neither hyperplastic nor hypertrophic growth of both cell types. However, SM3 (40 μg/ml) attenuated the positive chronotropic responsiveness of cardiomyocytes to Ang II (1 nM) stimulation, whereas Ang II-induced increase in non-cardiomyocyte number was decreased only by SM2 (40 μg/ml) treatment. Furthermore, SM3 suppressed Ang II-induced enlargement of cell size by preceding Ang II-induced induction of immediate early response gene (c-jun) expression in cardiomyocytes, while SM2 decreased Ang II-induced DNA synthesis in non-cardiomyocytes. Moreover, three phenolic compounds and tanshinone IIA that differed quantitatively among three SM fractions were identified by reverse-phase high performance liquid chromatography. Thus, the present findings indicate that the root of SM is an effective inhibitor of Ang II action and has a plural effective constituent, which possess different pharmacological activities on Ang II-induced hypertrophy and hyperplasia in cultured neonatal rat cardiac cells.

• 社団法人 日本薬理学会の論文
• 2001-12-01

著者

• Azuma Junichi

  Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical S

• Nakamura Norio

  Institute Of Natural Medicine University Of Toyama

• HATTORI Masao

  Institute of Natural Medicine, University of Toyama

• Komatsu Katsuko

  Institute of Natural Medicine, University of Toyama

• Azuma Junichi

  Department Of Clinical Evaluation Of Medicines And Therapeutics Graduate School Of Pharmaceutical Sc

• Hattori Masao

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Hattori M

  Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University

• TAKAHASHI Kyoko

  Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s U

• Nakamura N

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Ouyang Xinshou

  Departments Of Clinical Evaluation Of Medicines And Therapeutics Graduate School Of Pharmaceutical S

• Komatsu Katsuko

  富山大学和漢医薬学総合研究所

• Komatsu K

  Div. Of Pharmacognosy Dep. Of Medicinal Resources Inst. Of Natural Medicine Univ. Of Toyama

• Komatsu Katsuko

  Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine Toyama Med

• BABA Akemichi

  Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University

• Komatsu K

  Institute Of Natural Medicine University Of Toyama

• Komatsu Katsuko

  Institute Of Natural Medical Toyama Medicine And Pharmaceutical University

• Baba Akemichi

  Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka University

• Komatsu Katsuko

  Division Of Pharmacognosy Department Of Medicinal Resources Istitute Of Natural Medicine University

• Hattori Masao

  Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences

• Takahashi Kyoko

  Department Of Food Science And Nutrition School Of Human Environmental Sciences Mukogawa Women'

• Takahashi Kyoko

  Departments Of Clinical Evaluation Of Medicines And Therapeutics Graduate School Of Pharmaceutical S

• Azuma Junichi

  Departments Of Clinical Evaluation Of Medicines And Therapeutics Graduate School Of Pharmaceutical S

• Nakamura Norio

  Institute Of Natural Medicine Toyama And Pharmaceutical University

• Nakamura Norio

  Institute Of Natural Medicine

• Takahashi Kyoko

  Department Of Chemical And Biological Sciences Faculty Of Science Japan Women's University

• Takahashi Kyoko

  Department Of Bioproduction Science Faculty Of Horticulture Chiba University

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