Adrenergic β_1 Receptor Polymorphism (Ser49Gly) Is Associated with Obesity in Type II Diabetic Patients(Miscellaneous)

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In the process of lipolysis, adipocytes are stimulated by catecholamines through β_1, β_2, and β_3 adrenergic receptors (ARs). So far, β_2 and β_3, AR polymorphisms have been reported related to obesity. However, the relation of β_1AR polymorphisms to obesity has not been evaluated. In the present study, we examined whether βAR polymorphisms are associated with obesity-related phenotype in type II diabetic patients. Polymorphisms of β_1Ser49Gly, β_1Arg389Gly, β_2Arg16Gly, β_2Gln27Glu and β_3Trp64Arg were genotyped in 188 type II diabetic patients by PCR-RFLP. Among these polymorphisms, β_1Ser49Gly was found to be associated with obesity. Subjects with β_1Gly49 allele showed higher body mass index (BMI) than those with Ser49/Ser49 genotype (24.7±3.7 vs. 23.4±3.3 kg/m^2; p=0.031). Subjects with (β_1Gly49 allele were more frequently overweight (BMI≥25 kg/m^2) compared with β_1Ser49 homozygous group (42.1 vs. 24.4%, p=0.015). By multiple linear regression analysis, β_1Ser49Gly polymorphism was independently associated with higher BMI (p=0.019, β=0.166). Our data indicate that the Gly49 allele in β_1AR is associated with higher BMI in type II diabetic patients. Genotyping for β_1Ser49Gly polymorphism in type II diabetic patients may have clinical benefit to predict obesity, thereby contributing to the prevention of insulin resistance.
公益社団法人日本薬学会の論文
2008-02-01