Anti-complementary Activity of Triterpenoides from Fruits of Zizyphus jujuba(Pharmacognosy)

スポンサーリンク

概要

• 論文の詳細を見る

• In order to determine on the anti-complement activity of triterpenes, following eleven triterpenoides were isolated from the fruits of the Zizyphus jujuba MILL: ceanothane-type triterpenes: colubrinic acid (1), zizyberenalic acid (11); lupane-type triterpenes: alphitolic acid (2), 3-O-cis-p-coumaroyl alphitolic acid (3), 3-O-trans-pcoumaroyl alphitolic acid (4), betulinic acid (7), betulonic acid (9); and oleanane-type triterpenes: 3-O-cis-p-coumaroyl maslinic acid (5), 3-O-trans-p-coumaroyl maslinic acid (6), oleanolic acid (8), oleanonic acid (10). These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 5, 6, and 8 exhibited significant anti-complement activity with IC_<50> values of 101.4, 143.9, and 163.4 μM, respectively, whereas the ceanothane-type and the lupane-type triterpenes were inactive. This suggests that the oleanane-structure plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.

• 公益社団法人日本薬学会の論文
• 2004-11-01

著者

• Kinjo Junei

  福岡大学 薬学部

• Kinjo Junei

  熊本大学 薬

• Lee Hyeong-kyu

  韓国

• Lee Hyeong-kyu

  Korea Research Institute Of Bioscience And Biotechnology

• Min Byung-sun

  Coll. Of Pharmacy Catholic Univ. Of Daegu

• Min B‐s

  College Of Pharmacy Catholic University Of Daegu

• Min Byung

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Lee S‐y

  Kt&g Central Research Institute

• 金城 順英

  熊本大学 薬

• Jung K

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Lee Hyeong-kyu

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Lee Sun-young

  Department Of Oriental Pharmaceutical Science And Kyung Hee East-west Pharmaceutical Research Instit

• Min Byung

  College Of Pharmacy Catholic University Of Daegu

• Kim J‐h

  Korea Res. Inst. Of Bioscience And Biotechnology Daejeon Kor

• Kinjo J

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Kim J-h

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Min Byung-sun

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• LEE Sang-Myung

  KT&G Central Research Institute

• Jung K

  Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor

• Lee Hyeong-kyu

  Korea Res. Inst. Of Bioscience And Biotechnology

• Lee Hyeong-kyu

  Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog

• PARK Jin-Gyu

  KT&G Central Research Institute

• LEE You-Hee

  KT&G Central Research Institute

• LEE Cheal-Gyu

  Department of Environmental Engineering, Chongju University

• KIM Jung-Hee

  Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology

• Lee You-hee

  Kt&g Central Research Institute

• Park Jin-gyu

  Kt&g Central Research Institute

• Lee Cheal-gyu

  Department Of Environmental Engineering Chongju University

• Min Byung

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Kinjyo Junei

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Lee S‐m

  Kyung‐hee Univ. Seoul Kor

関連論文

• Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains
• Development of an Enzyme Linked Immunosorbent Assay for Direct Determination of Anticancer Drug Vitamin K3 in Serum
• Pharmacological Study on the Novel Antinociceptive Agent, a Novel Monoterpene Alkaloid from Incarvillea sinensis(Pharmacognosy)
• A new lignan glucoside from the stems of Callicarpa japonica Thunb. var. luxurians Rehd.
• Five New Diterpenoids, Viteagnusins A-E, from the Fruit of Vitex agnus-castus
• HPLC Profile Analysis of Hepatoprotective Oleanene-Glucuronides in Puerariae Flos
• Three New Anti-Oxidative Saponarin Analogs from Young green Barley Leaves
• Structures of Three New Oleanene Glucuronides Isolated from Lathyrus palustris var. pilosus and Hepatoprotective Activity
• A New Oleanene Glucuronide Having a Branched-Chain Sugar from Melilotus officinalis
• Antinociceptive Activities of α-Truxillic Acid and β-Truxinic Acid Derivatives(Pharmacognosy)
• Anti-inflammatory Activity of 4,4'-Dihydroxy-α-truxillic Acid(Pharmacognosy)
• Quantitative Determination of Incarvillateine in Incarvillea sinensis by Solid Phase Extraction and High Performance Liquid Chromatography
• Anti-inflammatory Activities of α-Truxillic Acid Derivatives and Their Monomer Components(Medicinal Chemistry)
• A Monoterpene Alkaloid from Incarvillea sinensis
• Two Novel Actinidine-Type Monoterpene Alkaloids from Incarvillea delavayi
• Studies on the Constituents of Gueldenstaedtia multiflora
• Three New Monoterpenoids from the Fruit of Genipa americana
• Trypanocidal Constituents in Plants 6. Minor Withanolides from the Aerial Parts of Physalis angulata
• ウスバサイシンAsiasarum sieboldii F. Maekawaの発芽特性
• Anti-herpes Virus Type 1 Activity of Oleanane-Type Triterpenoids(Pharmacognosy)
• New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis
• Trypanocidal Constituents in Plants 5. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in the Seeds of Persea americana(Pharmacognosy)
• Examination for Estrogenic Activities of Soyasaponin I and Related Compounds
• Soy Isoflavone Metabolites Isolated from Human Urine
• Hepatoprotective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Their Glucuronides on the Cytotoxicity of tert-Butyl Hydroperoxide to HepG2 Cells(Pharmacognosy)
• Sesquiterpenoids, Triterpenoids, and Flavonoids from the Fruits of Schinus molle
• Two new lignan glucosides from the fruit of Vitex cannabifolia
• Two Novel Antioxidant Ortho-Benzoyloxyphenyl Acetic Acid Derivatives from the Fruit of Vaccinium uliginosum
• Quantitative Determination of Bitter Principles in Specimens of Ganoderma lucidum Using High-Performance Liquid Chromatography and Its Application to the Evaluation of Ganoderma Products
• Antiproliferative Activity of Phenylpropanoid Ester Glycosides from Ligustrum purpurascens
• Enantioselective Dehydroxylation of Enterodiol and Enterolactone Precursors by Human Intestinal Bacteria(Pharmacognosy)
• The Heterocyclic Ring Fission and Dehydroxylation of Catechins and Related Compounds by Eubacterium sp.Strain SDG-2, a Human Intestinal Bacterium
• Triterpenes from the Spores of Ganoderma lucidum and Their Cytotoxicity against Meth-A and LLC Tumor Cells
• Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activites by Constituents of Juglans mandshurica
• Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-1 Protease
• Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum
• In vivo antitumor effects of bitter principles from the antlered form of fruiting bodies of Ganoderma lucidum
• Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
• Anti-amnestic Activity of Pseudocoptisine from Corydalis Tuber(Pharmacognosy)
• Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity
• Cytotoxicity of Triterpenes Isolated from Aceriphyllum rossii
• Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
• Anticancer Constituents from the Roots of Rubia cordifolia L.
• Anti-herpes Virus Activity of Fabaceous Triterpenoidal Saponins
• Lignans and Coumarins from the Roots of Anthriscus sylvestris and Their Increase of Caspase-3 Activity in HL-60 Cells(Pharmacognosy)
• Increase of Caspase-3 Activity by Lignans from Machilus thunbergii in HL-60 Cells(Pharmacognosy)
• Effects of Oleanane-Type Triterpenoids from Fabaceous Plants on the Expression of ICAM-1
• Androstane Alkaloids from Musk of Moschus moschiferus
• Inhibitory Activity of Lignan Components from the Flower Buds of Magnoliae fargesii on the Expression of Cell Adhesion Molecules
• Semialactone, Isofouquierone Peroxide and Fouquierone, Three New Dammarane Triterpenes from Rhus javanica
• Structure-Activity Relationships of Lignans from Schisandra chinensis as Platelet Activating Factor Antagonists
• Anti-complement Activity of Tiliroside from the Flower Buds of Magnolia fargesii
• The Seed Extract of Cassia obtusifolia Ameliorates Learning and Memory Impairments Induced by Scopolamine or Transient Cerebral Hypoperfusion in Mice
• Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats(Pharmacology)
• Iridoid Esters from Patrinia saniculaefolia
• Acylated Flavonol Glycosides with Anti-complement Activity from Persicaria lapathifolia
• Partial Hydrolysis of Soyasaponin I and the Hepatoprotective Effects of the Hydrolytic Products. Study of the Structure-Hepatoprotective Relationship of Soyasapogenol B Analogs
• A New Naphthopyrone from the Root of Pleuropterus ciliinervis
• Antioxidant Activity of Two Phloroglucinol Derivatives from Dryopteris crassirhizoma(Pharmacognosy)
• Anti-complementary Activity of Ursane-Type Triterpenoids from Weigela subsessilis(Pharmacognosy)
• Platelet Activating Factor Antagonist Activity of Ginsenosides
• Antioxidative Substances in the Leaves of Ligustrum purpurascens
• Inhibition of Human Low Density Lipoprotein and High Density Lipoprotein Oxidation by Oligostilbenes from Rhubarb(Pharmacognosy)
• Effect of Astilbe koreana on Ultraviolet B (UVB)-Induced Inflammatory Response in Human Keratinocytes(Pharmacognosy)
• Microbial metabolism of soy isoflavones by human intestinal bacterial strains
• Construction and Expression of Specificity-Improved Single-Chain Variable Fragments against the Bioactive Naphthoquinone, Plumbagin(Pharmacognosy)
• Hepatoprotective constituents in plants 15: protective effects of natural-occurring flavonoids and miscellaneous phenolic compounds as determined in an HepG2 cell cytotoxicity assay
• Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica(Pharmacognosy)
• Ginsenosides from Heat Processed Ginseng
• Magnoflorine from Coptidis Rhizoma Protects High Density Lipoprotein during Oxidant Stress(Pharmacognosy)
• Anti-complementary Activity of Triterpenoides from Fruits of Zizyphus jujuba(Pharmacognosy)
• Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica
• Interactions of Phytoestrogens with Estrogen Receptors α and β(III). Estrogenic Activities of Soy Isoflavone Aglycones and Their Metabolites Isolated from Human Urine(Toxicology)
• Ursolic Acid as a Trypanocidal Constituent in Rosemary
• Activity-Guided Fractionation of Green Tea Extract with Antiproliferative Activity against Human Stomach Cancer Cells
• Antiproliferative Constituents in Plants 10. Flavones from the Leaves of Lantana montevidensis BRIQ. and Consideration of Structure-Activity Relationship
• New Triterpene Aldehydes, Lucialdehydes A-C, from Ganoderma lucidum and Their Cytotoxicity against Murine and Human Tumor Cells
• Study of Structure-Hepatoprotective Relationships of Oleanene-Type Triterpenoidal Glucuronides Obtained from Several Fabaceous Plants on Rat Primary Hepatocyte Cultures
• Hepatoprotective and Hepatotoxic Actions of Oleanolic Acid-Type Triterpenoidal Glucuronides on Rat Primary Hepatocyte Cultures
• Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum
• Kaempferol Acetylrhamnosides from the Rhizome of Dryopteris crassirhizoma and Their Inhibitory Effects on Three Different Activities of Human Immunodeficiency Virus-1 Reverse Transcriptase
• Triterpenes and Lignans from Artemisia caruifolia and Their Cytotoxic Effects on Meth-A and LLC Tumor Cell Lines
• Hepatoprotective and Hepatotoxic Activities of Sophoradiol Analogs on Rat Primary Liver Cell Cultures
• Five Triterpene Glycosides from Oxytropis myriophylla
• Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis
• Lignans from the Fruits of Forsythia suspensa (Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress
• Interaction of Phytoestrogens with Estrogen Receptors α and β(II)
• DPPH(1, 1-Diphenyl-2-Picrylhydrazyl)Radical Scavenging Activity of Flavonoids Obtained from Some Medicinal Plants
• Interaction of Phytoestrogens with Estrogen Receptors α and β
• Synthesis of Neosaponins Carrying Oligosaccharides from Natural Products
• A New Oleanene Glucuronide Obatined from the Aerial Parts of Melilotus officinalis
• Antioxidative Activities of Galloyl Glucopyranosides from the Stem-Bark of Juglans mandshurica
• Lignans from the Fruits of Forsythia suspensa (Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress
• Three new aromatic glycosides from the ripe fruit of cherry tomato
• Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside
• Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents
• Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
• Components of convolvulin from Quamoclit×multifida
• Development of an enzyme-linked immunosorbent assay to determine puerarin and its aglycone daidzein
• Screening of promising chemotherapeutic candidates against human adult T-cell leukemia/lymphoma from plants : active principles from Physalis pruinosa and structure-activity relationships with withanolides

もっと見る 閉じる

スポンサーリンク