Lignans from the Fruits of Forsythia suspensa (Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress
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概要
- 論文の詳細を見る
The objective of the present study was to investigate the beneficial properties lignan compounds obtained from the fruits of Forsythia suspensa (Thunb.) Vahl (Oleaceae) for protecting human high-density lipoprotein (HDL) against lipid peroxidation. The isolated compounds (1–8) inhibited the generation of thiobarbituric acid-reactive substances (TBARS) in a dose-dependent manner with IC50 values from 8.5 to 18.7 μM, since HDL oxidation mediated by catalytic Cu2+. They also exerted an inhibitory effect against thermo-labile radical initiator (AAPH)-induced lipid peroxidation of HDL with IC50 values from 12.1 to 51.1 μM. Compounds 1 and 5 exerted inhibitory effects against the Cu2+-induced lipid peroxidation of HDL, as shown by an extended lag time prolongation at the concentration of 3.0 μM. These results suggest that the antioxidative effects of F. suspensa are due to its lignans and that these constituents may be useful for preventing the oxidation of HDL.
- 社団法人 日本農芸化学会の論文
- 2008-10-23
著者
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BAE KiHwan
College of Pharmacy, Chungnam National University
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金城 順英
熊本大学 医薬
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BAE Ki
College of Pharmacy, Chungnam National University
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Bae Ki
College Of Pharmacy Chungnam National University
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Bae Kihwan
韓国
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Kinjo Junei
東海大学 農学部
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Kinjo Junei
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Lee Hyeong-kyu
韓国
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Lee Hyeong-kyu
Korea Research Institute Of Bioscience And Biotechnology
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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CHOI Jae
Faculty of Food Science and Biotechnology, Pukyong National University
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Woo Mi
College Of Pharmacy Catholic University Of Daegu
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Min Byung-sun
College Of Pharmacy Catholic University Of Daegu
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Bae Kihwan
College Of Pharmacy Chungnam National University
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CHANG Min-Jung
College of Pharmacy, Catholic University of Daegu
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KIM Jin-Cheol
Korea Research Institute of Chemical Technology
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Choi J
Pukyong National Univ. Busan Kor
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Choi Jae
Faculty Of Food Science And Biotechnology Pukyong National University
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Kinjo J
Faculty Of Pharmaceutical Sciences Fukuoka University
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Min Byung-sun
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Korea Res. Inst. Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Min Byung
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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HUNG Tran
Korea Research Institute of Bioscience and Biotechnology
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LEE Hyeong
Korea Research Institute of Bioscience and Biotechnology
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Hung Tran
College Of Pharmacy Catholic University Of Daegu
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Chang Min-jung
College Of Pharmacy Catholic University Of Daegu
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Bae K
College Of Pharmacy Chungnam National University
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