Gymnasterkoreayne G, a New Inhibitory Polyacetylene against NFAT Transcription Factor from Gymnaster koraiensis

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概要

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• A new polyacetylene, gymnasterkoreayne G (1) and seven known (2-8) constituents were isolated from the leaves of Gymnaster koraiensis. Base on extensive 1D and 2D NMR spectroscopic data, the structure of the new compound was identified as erythro-8(S)-9(Z), 16-heptadecadiene-4, 6-diyne-2, 3, 8-triol. Isolated compounds were evaluated for their ability to inhibit NFAT transcription factor. While other components did not show activity, most of polyacetylene components markedly inhibit NFAT transcription factor. Of these compounds, gymnasterkoreayne B (3) was the most potent (IC_<50> 1.44±0.59μM). In term of the isomers, compound 1 (IC_<50> 43.9±2.24μM) with an erythro-configuration showed less inhibition than 2 (IC_<50> 7.24±0.42μM) with a threo-configuration.

• 公益社団法人日本薬学会の論文
• 2005-09-01

著者

• Kim Young

  College of Pharmacy, Chungnam National University

• BAE KiHwan

  College of Pharmacy, Chungnam National University

• Kwon Young-in

  Dep. Of Food And Nutrition Hannam Univ.

• LEE Eun

  College of BioNano Technology, Kyungwon University

• Park Yong

  Department of Genetic Engineering, Kyungpook National University

• Kim Young

  Coll. Of Pharmacy Chungnam National Univ.

• CAI Xing

  College of Pharmacy, Chungnam National University

• Lee I

  College Of Pharmacy Chungnam National University

• Dat N

  College Of Pharmacy Chungnam National University

• Dat Nguyen

  College Of Pharmacy Chungnam National University

• Cai X

  College Of Pharmacy Chungnam National University

• Cai Xing

  College Of Pharmacy Chungnam National University

• Bae Kihwan

  College Of Pharmacy Chungnam National University

• Park Yong

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Kim Y

  College Of Pharmacy Chungnam National University

• Kim Young

  Korea University

• Kim Young

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Cai Xing

  Korea Res. Inst. Of Bioscience And Biotechnology Kor

• Lee Im

  College Of Pharmacy Chungnam National University

• Lee Eun

  College Of Pharmacy Chungnam National University

• SHEN Quanghai

  College of Pharmacy, Chungnam National University

• Lee I

  Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor

• Shen Quanghai

  College Of Pharmacy Chungnam National University

• Lee Eun

  College Of Bionano Technology Kyungwon University

• Kim Young

  Colledge of Pharmacy, Wonkwang University

• Park Yong

  Department of Advanced Materials, Engineering for Information and Electronics, Kyung Hee University, Yongin 446-701, Korea

• Park Yong

  Department of Advanced Materials Engineering, Kyonggi University, Suwon, Gyeonggi-do 443-760, Republic of Korea

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