TWEAK Can Induce Pro-Inflammatory Cytokines and Matrix Metalloproteinase-9 in Macrophages

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概要

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• The expression of TWEAK (TNFSF12) and TweakR/Fn14 was detected in regions rich in macrophage/foam cells in atherosclerotic plaques. The role of TWEAK in monocytes in relation to atherogenesis was investigated by analyzing the cellular events induced by TWEAK in a human macrophage-like cell line, THP-1. TWEAK induced various molecular mediators of atherogenesis, such as IL-6, MCP-1, IL-8 and MMP-9, and the induction was augmented by interferon-γ. TWEAK-induced activation of MMP-9 was mediated by activation of NF-_κB. These results suggest that TWEAK is involved in atherosclerosis by inducing pro-inflammatory cytokines and extracellular matrix degrading enzymes, which reduce plaque stability.

• 2004-03-20

著者

• Kim Se-hwa

  Cardiology Division Samsung Medical Center Sungkyunkwan University School Of Medicine

• Kang Yoon-Joong

  Department of Genetic Engineering, Kyungpook National University

• Kim Won-Jung

  Department of Genetic Engineering, Kyungpook National University

• Woo Dong-Kyun

  Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine

• Lee Yoon

  Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine

• Kim Dong-Ik

  Division of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine

• Park Yong

  Department of Genetic Engineering, Kyungpook National University

• Kwon Byoung

  Immunomodulation Research Center, University of Ulsan

• Park Jeong-Euy

  Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine

• Lee Won-Ha

  Department of Genetic Engineering, Kyungpook National University

• Park Jeong-euy

  Cardiology Division Samsung Medical Center Sungkyunkwan University School Of Medicine

• Kang Yoon-joong

  Department Of Genetic Engineering Kyungpook National University

• Park Yong

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Kim Dong-ik

  Division Of Vascular Surgery Samsung Medical Center Sungkyunkwan University School Of Medicine

• Kwon Byoung

  Immunomodulation Research Center University Of Ulsan

• Woo Dong-kyun

  Cardiology Division Samsung Medical Center Sungkyunkwan University School Of Medicine

• Lee Won-ha

  Department Of Genetic Engineering Kyungpook National University

• Kim Won-jung

  Department Of Genetic Engineering Kyungpook National University

• Park Yong

  Department Of Genetic Engineering Kyungpook National University

• Lee Yoon

  Cardiology Division Samsung Medical Center Sungkyunkwan University School Of Medicine

• Park Yong

  Department of Advanced Materials, Engineering for Information and Electronics, Kyung Hee University, Yongin 446-701, Korea

• Park Yong

  Department of Advanced Materials Engineering, Kyonggi University, Suwon, Gyeonggi-do 443-760, Republic of Korea

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