Tumor Necrosis Factor Receptor Superfamily 12 may Destabilize Atherosclerotic Plaques by Inducing Matrix Metalloproteinases

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概要

• 論文の詳細を見る

• Immunohistochemical staining of human atherosclerotic plaques revealed expression of the tumor necrosis factor receptor superfamily(TNFRSF) 12 in regions rich in macrophage/foam cells. The role of TNFRSF12 in the functioning of monocytes in relation to atherogenesis was investigated by analysis of cellular events after stimulation of TNFRSF12 in a human macrophage-like cell line, THP-1. Activation of the THP-1 cells on plates coated with monoclonal antibody against TNFRSF12 induced the expression of matrix metalloproteinases(MMPs) -1, -9, and -13. Furthermore, the expression patterns of TNFRSF12 and the MMPs overlapped in atherosclerotic plaques. Signaling of TNFRSF12 may thus contribute to the induction of extracellular matrix degrading enzymes in macrophages.

• 社団法人日本循環器学会の論文
• 2001-01-20

著者

• Kim Se-hwa

  Cardiology Division Samsung Medical Center Sungkyunkwan University School Of Medicine

• Kwon Byoung

  Immunomodulation Research Center, University of Ulsan

• Park Jeong-Euy

  Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine

• Lee Won-Ha

  Department of Genetic Engineering, Kyungpook National University

• Park Jeong-euy

  Cardiology Division Samsung Medical Center Sungkyunkwan University School Of Medicine

• Lee Won-Ha

  Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine

• Oh Goo

  Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology

• Choi Yoon-Ho

  Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine

• Kwon Byoung

  Immunomodulation Research Center University Of Ulsan

• Choi Yoon-ho

  Cardiology Division Samsung Medical Center Sungkyunkwan University School Of Medicine

• Lee Won-ha

  Department Of Genetic Engineering Kyungpook National University

• Oh Goo

  Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology

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