Zeaxanthin Dipalmitate from Lycium chinense Fruit Reduces Experimentally Induced Hepatic Fibrosis in Rats

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概要

• 論文の詳細を見る

• We previously reported that zeaxanthin dipalmitate (ZD), a carotenoid from Lycium chinense fruit, reduces myofibroblast-like cell proliferation and collagen synthesis in vitro. To determine whether ZD might reduce the severity of hepatic fibrosis in an animal model, hepatic fibrosis was induced in rats by bile duct ligation/scission (BDL) for a period of 6 weeks. Treatment of BDL rats with ZD at a dose of 25mg/kg body weight significantly reduced the activities of aspartate transaminase (p<0.05) and alkaline phosphatase (p<0.001) in serum. Further-more, collagen deposition was significantly reduced as assessed by the Sirius Red binding assay in BDL rats administered ZD at the dose of 25mg/kg body weight (p<0.01). In addition, the levels of thiobarbituric acid-reactive substances and 4-hydroxyproline were reduced when BDL rats received ZD at the dose of 25mg/kg body weight. These results showed that ZD effectively inhibited hepatic fibrosis in BDL rats, at least in part via its antioxidative activity.

• 社団法人日本薬学会の論文
• 2002-03-01

著者

• KIM Sun

  Graduate School of East-West Medicine, Kyung Hee University

• Kim Young

  College of Pharmacy, Chungnam National University

• KIM Hong

  College of Medicine, Kohwang Medical Research Institute, Kyung Hee University

• Park Jae-hyuk

  Toyohashi Univ. Tech.

• Kim S

  Kyung Hee Univ. Seoul Kor

• Kim Yun

  Colledge Of Pharmacy Wonkwang University

• PARK Jong-Hwan

  Department of Laboratory Animal Medicine

• PARK Jae-Hak

  Department of Laboratory Animal Medicine

• Park Jae-hak

  Dep. Of Lab. Animal Medicine Coll. Of Veterinary Medicine And Krf Zoonotic Disease Priority Res. Ins

• Kim Y

  Seoul National Univ. Seoul Kor

• LEE Eun

  College of BioNano Technology, Kyungwon University

• 朴 載赫

  豊橋技科大

• Kim J

  Seoul National Univ. Seoul Kor

• Kim S

  Graduate School Of East-west Medicine Kyung Hee Univ.

• Kim Sun

  Graduate School Of East-west Medical Science Kyung Hee University

• Park J‐h

  Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University

• Kim Young

  Department Of Physiology And Biophysics Seoul National University College Of Medicine

• Lee E

  College Of Pharmacy Seoul National University

• KIM Jinwoong

  College of Pharmacy, Seoul National University

• KIM Hye

  College of Pharmacy, Seoul National University

• PARK Jae-Hak

  College of Veterinary Medicine, Seoul National University

• Kim Jinwoong

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Park J‐h

  Dep. Of Lab. Animal Medicine Coll. Of Veterinary Medicine And Krf Zoonotic Disease Priority Res. Ins

• Park Jong

  College Of Pharmacy Pusan National University

• Kim Young

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Kim H

  Department Of Food And Biotechnology Hanseo University

• Kim S

  Graduate School Of East-west Medical Science Kyung Hee University

• Kim Hong

  College Of Pharmacy Seoul National University

• Kim Hye

  College Of Pharmacy Seoul National University

• Kim Young

  Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.

• Kim Sun

  Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky

• Lee Eun

  College Of Bionano Technology Kyungwon University

• Kim Sun

  East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.

• Kim Sun

  Graduate School Of East-west Medical Science

• Kim Young

  Colledge of Pharmacy, Wonkwang University

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