(4-Methoxy-benzylidene)-(3-methoxy-phenyl)-amine, a Nitrogen Analog of Stilbene as a Potent Inhibitor of Melanin Production
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概要
- 論文の詳細を見る
The current study was carried out to investigate in vitro the effects of (4-methoxy-benzylidene)-(3-methoxy-phenyl)-amine on melanin biosynthesis which is closely related to hyper-pigmentation. (4-Methoxy-benzylidene)-(3-methoxy-phenyl)-amine, a nitrogen analog of stilbene, was synthesized by a single step process. This compound inhibited the tyrosinase activity, which converts dopa to dopachrome in the biosynthetic process of melanin, and showed a UV-blocking effect at UV-B band. The compound also exhibited SOD-like activity, which is involved in the protection against auto-oxidation and inhibited melanin production in melan-a cell line. Our results suggest the possibility that (4-methoxy-benzylidene)-(3-methoxy-phenyl)-amine might be used as a skin whitening agent.
- 公益社団法人日本薬学会の論文
- 2002-04-01
著者
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KIM Sun
Graduate School of East-West Medicine, Kyung Hee University
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Choi Sang
韓国
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Kim Sung-soo
Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University
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Kim H
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Kim S
Graduate School Of East-west Medicine Kyung Hee Univ.
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CHOI Sang
Graduate School of East-West Medical Science, Kyung Hee University
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KIM Hocheol
Graduate School of East-West Medical Science, Kyung Hee University
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Hwang Jae
Skin Research Institute Amorepacific R&d Center
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Hwang J
R & D Center Amore-pacific Corporation
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Kim Sun
Graduate School Of East-west Medical Science Kyung Hee University
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Hwang Jae
Skin Research Institute Pacific R & D
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KIM Sanghee
Natural Products Research Institute, College of Pharmacy, Seoul National University
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LEE Byeong
Skin Research Institute, Pacific R&D, Kyoungi-Do, Korea
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SUK Kyoungho
Graduate School of East-West Medical Science, Kyung Hee University
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KIM Ae-Jung
Hyejeon College
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Kim Hong
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Kim S
Graduate School Of East-west Medical Science Kyung Hee University
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Lee B
R & D Center Amore-pacific Corporation
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Kim Sanghee
Natural Products Research Institute College Of Pharmacy Seoul National University
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Suk Kyoungho
Graduate School Of East-west Medical Science Kyung Hee University
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Choi S
Kyung Hee Univ. Seoul Kor
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Hwang Jae
Skin Research Institute Amorepacific Corporation/r&d Center
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Kim H
Graduate School Of East-west Medical Science Kyung Hee University
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Lee Byeong
Skin Research Institute Amorepacific Corporation/r&d Center
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Kim Sun
Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky
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Kim Sun
East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.
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Kim Sun
Graduate School Of East-west Medical Science
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