Depigmenting Activity and Low Cytotoxicity of Alkoxy Benzoates or Alkoxy Cinnamte in Cultured Melanocytes
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概要
- 論文の詳細を見る
To obtain effective and safe topical depigmenting agents, we synthesized hydroxybenzoates, alkoxybenzoates, and 3, 4, 5-trimethoxycinnamate containing a thymol moiety and screened then for high-level inhibitory activity against melanin synthesis in cultured melanocytes. Eight compounds were tested for their depigmenting effect and cytotoxicity using a murine melanocyte cell line. We found that 3, 4, 5-trialkoxybenzoates and 3, 4, 5-trimethoxycinnamate, synthesized by conjugating 3,4,5-trialkoxybenzoic acids and 3,4,5-trimethoxycinnmic acid with thymol, showed a potent depigmenting effect and low cytotoxicity. Compound 4h, 5-methyl-2-(methylethyl) phenyl (2E)-3-(3, 4, 5-trimethoxyphenyl) prop-2-enoate, showed the most potent depigmenting effect (IC_<50>=10μM) with low cytotoxicity (IC_<50>=200μM).
- 公益社団法人日本薬学会の論文
- 2003-09-01
著者
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Hwang J
R & D Center Amore-pacific Corporation
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Hwang Jae
Skin Research Institute Pacific R & D
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KANG HAK
Department of Chemical Engineering, College of Engineering, Hanyang University
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RHO Ho
R & D Center, Amore-Pacific Corporation
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HWANG Jae
R & D Center, Amore-Pacific Corporation
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OH Scong-Gcon
Department of Chemical Engineering, College of Engineering, Hanyang University
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Rho Ho
R & D Center Amore-pacific Corporation
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Kang Hak
Department Of Chemical Engineering College Of Engineering Hanyang University
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Oh Scong-gcon
Department Of Chemical Engineering College Of Engineering Hanyang University
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- Depigmenting Activity and Low Cytotoxicity of Alkoxy Benzoates or Alkoxy Cinnamte in Cultured Melanocytes
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