Mulberroside F Isolated from the Leaves of Morus alba Inhibits Melanin Biosynthesis

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概要

• 論文の詳細を見る

• The current study was carried out to investigate the in vitro effects of an 85% methanol extract of dried Morus alba leaves on melanin biosynthesis, which is closely related to hyperpigmentation. These extracts inhibited the tyrosinase activity that converts dopa to dopachrome in the biosynthetic process of melanin. Mulberroside F (moracin M-6, 3'-di-O-β-D-glucopyranoside), which was obtained after the bioactivity-guided fractionation of the extracts, showed inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. This compound also exhibited superoxide scavenging activity that is involved in the protection against autooxidation. But its activity was low and was weaker than of kojic acid. These results suggest that mulberroside F isolated from mulberry leaves might be used as a skin whitening agent.

• 公益社団法人日本薬学会の論文
• 2002-08-01

著者

• LEE Sang

  Department of Pulmonary and Critical Care Medicine, Gachon University, Gil Medical Center

• Kim Sun

  Department Of Chemical Engineering Sogang University

• Choi Sang

  韓国

• Choi Sang

  Department Of Physics Korea University

• Kim Sung-soo

  Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University

• Kim H

  Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University

• Kim S

  Graduate School Of East-west Medicine Kyung Hee Univ.

• Hwang Jae

  Skin Research Institute Amorepacific R&d Center

• Hwang J

  R & D Center Amore-pacific Corporation

• Kim Sun

  Graduate School Of East-west Medical Science Kyung Hee University

• Hwang Jae

  Skin Research Institute Pacific R & D

• Lee Sang

  Department Of Advanced Materials Science And Engineering Mokpo National University

• Lee S

  Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyunghee University

• KIM Hocheol

  Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyunghee University

• LEE Byeong

  Skin Research Institute, Pacific R&D, Kyoungi-Do, Korea

• GAO Jian

  School of Pharmaceutical Science, Beijing Medical University

• Kim Hong

  Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University

• Gao Jian

  School Of Pharmaceutical Science Beijing Medical University

• Kim S

  Graduate School Of East-west Medical Science Kyung Hee University

• Gao J

  School Of Pharmaceutical Science Beijing Medical University

• Lee B

  R & D Center Amore-pacific Corporation

• Choi S

  Kyung Hee Univ. Seoul Kor

• Kim Sun

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

• Hwang Jae

  Skin Research Institute Amorepacific Corporation/r&d Center

• Kim H

  Graduate School Of East-west Medical Science Kyung Hee University

• Kim Hocheol

  Department Of Herbal Pharmacology College Of Oriental Medicine Kyung Hee University:korea Institute

• Choi Sang

  Department Of Food Science And Nutrition Catholic University Of Daegu

• Lee Byeong

  Skin Research Institute Amorepacific Corporation/r&d Center

• Choi Sang

  Department Of Biological Sciences And The Immunomodulation Research Center University Of Ulsan

• Choi Sang

  Department Of Agricultural Chemistry Gyeongsang National University

• Kim Sun

  East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.

• Kim Sun

  Department Of Animal Science And Technology Seoul National University

• LEE Sang

  Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University

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