Associations Between Lipid Measures and Metabolic Syndrome, Insulin Resistance and Adiponectin : Usefulness of Lipid Ratios in Korean Men and Women
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概要
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Background: Several reports have raised the possibility that newly addressed lipid measures might be superior to the traditional ones for cardiovascular risk prediction. However, data on the associations between these lipid measures with metabolic syndrome (MetS) is limited. Methods and Results: A cross-sectional study of participants in routine health examinations was performed. The associations between lipid measure variables (total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TC/HDL-C, LDL-C/HDL-C, TG/HDL-C ratio and non-HDL-C) and MetS, insulin resistance (IR) by homeostatic model assessment (HOMA) and adiponectin were analyzed in 6,546 participants (3,820 men; mean age 46.0±9.2 years in men, 44.6±9.5 years in women). In multivariable adjusted regression analysis, the 3 lipid ratios of TC/HDL-C, LDL-C/HDL-C and TG/HDL-C showed significant association with the number of MetS components, HOMA and log adiponectin level in both men and women without MetS (P<0.001, respectively), though these relations were weaker in participants with MetS. The mean levels of the lipid ratios also associated with increasing numbers of the MetS components, quartiles of HOMA and adiponectin. Conclusions: Lipid ratios of TC/HDL-C, LDL-C/HDL-C and TG/HDL-C, as well as TG and HDL, were consistently associated with MetS and IR in participants without MetS. Lipid ratios might be used as integrated and simple lipid measures.
- 2010-04-25
著者
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LEE Sang
Department of Pulmonary and Critical Care Medicine, Gachon University, Gil Medical Center
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KIMM Heejin
Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of
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LEE Hong
Department of Family Medicine, School of Medicine, Ewha Womans University
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SHIM Kyung
Department of Family Medicine, School of Medicine, Ewha Womans University
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CHO Choo
Department of Family Medicine, Soonchunhyang University College of Medicine
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YUN Ji
Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of
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JEE Sun
Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of
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Kimm Heejin
Institute For Health Promotion & Department Of Epidemiology And Health Promotion Graduate School
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Cho Choo
Department Of Family Medicine Soonchunhyang University College Of Medicine
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Shim Kyung
Department Of Family Medicine School Of Medicine Ewha Womans University
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Lee Sang
Department Of Advanced Materials Science And Engineering Mokpo National University
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Lee Hong
Department Of Family Medicine School Of Medicine Ewha Womans University
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Lee Hong
Department Of Ceramic Engineering Yonsei University
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Lee Sang
Department Of Family Medicine School Of Medicine Ewha Womans University
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Yun Ji
Institute For Health Promotion Yonsei University
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Jee Sun
Institute For Health Promotion Yonsei University
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Kimm Heejin
Institute For Health Promotion & Department Of Epidemiology And Health Promotion Graduate School
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Yun Ji
Institute For Health Promotion & Department Of Epidemiology And Health Promotion Graduate School
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Lee Hong
Department Of Bio-resources And Pnu-special Animal Biotechnology Center College Of Natural Resources & Life Science Pusan National University
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Yun Ji
Department Of Rehabilitation Standard & Policy Korea National Rehabilitation Research Institute
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LEE Sang
Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University
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