Microbial Transformation of Terreusinone, an Ultraviolet-A (UV-A) Protecting Dipyrroloquinone, by Streptomyces sp.

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概要

• 論文の詳細を見る

• Biotransformation study was conducted on the marine dipyrroloquinone, terreusinone (1) isolated from the marine-derived fungus Aspergillus terreus. Preparative-scale fermentation of terreusinone with Streptomyces sp. has resulted in the isolation of a new oxidized metabolite, terreusinol (2). The structure was elucidated as 2-[(1R)-1-hydroxyisobutyl]-6-[(1R)-1,2-dihydroxyisobutyl]-1H,5H-pyrrolo[2,3-6]indole-4,8-dione (2) on the basis of physicochemical evidence. Terreusinol (2) showed an ultraviolet-A (UV-A) (320-390 nm) protecting activity with ED_<50> values of 150μM, which is more active than oxybenzone (ED_<50>,350μM) currently being used as sunscreen.

• 社団法人日本薬学会の論文
• 2003-12-01

著者

• LEE Sang

  Department of Pulmonary and Critical Care Medicine, Gachon University, Gil Medical Center

• Choi Hong

  Department of Korean Internal Medicine, College of Oriental Medicine, Daegu Haany University

• Kang Jung

  College Of Dentistry Pusan National University

• Choi Hong

  Department Of Chemistry Dongeui University

• LI Xifeng

  Department of Chemistry, Pukyong National University

• SON Byeng

  Department of Chemistry, Pukyong National University

• Son B

  Department Of Chemistry Pukyong National University

• Lee Sang

  Department Of Advanced Materials Science And Engineering Mokpo National University

• Son Byeng

  Department Of Chemistry Pukyong National University

• Li Xifeng

  Department Of Chemistry Pukyong National University

• Lee Sang

  Department Of Chemistry Pukyong National University

• LEE Sang

  Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University

• Choi Hong

  Department of Applied Physics, Korea University, Seoul 136-713, Korea

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