Lack of Additional Benefit of Intracoronary Transplantation of Autologous Peripheral Blood Stem Cell in Patients With Acute Myocardial Infarction
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概要
- 論文の詳細を見る
Background Recently the potential of myocardial repair by transplantation of autologous bone marrow stem cells has been suggested. Whether the additional intracoronary transplantation of autologous peripheral blood stem cells (PBSC), which were mobilized by granulocyte-colony-stimulating factor (G-CSF), could safely improve myocardial function in patients with acute myocardial infarction (AMI) was investigated. Methods and Results Seventy-three patients with AMI who had successfully undergone percutaneous coronary intervention (PCI) were enrolled in the present prospective nonrandomized open-labeled study. Ten patients with elective PCI received G-CSF for 4 days followed by intracoronary PBSC transplantation. Thirty-two patients with primary PCI and 31 patients with recent AMI and elective PCI served as controls. The left ventricular (LV) function was evaluated using echocardiography and magnetic resonance imaging. G-CSF and intracoronary transplantation of PBSC did not incur any periprocedural myocardial damage. After 6 months, the LV ejection fraction was significantly improved in the cell therapy group. For 2 years of the follow-up period, there was no adverse clinical events, except one asymptomatic instent restenosis. However, comparable improvement of the LV ejection fraction was also identified in the primary PCI and elective PCI control groups. Conclusions In the present study, additional intracoronary infusion of PBSC was safe and feasible for the patients with AMI who had undergone PCI, but did not lead to a significant improvement in LV function compared to standard reperfusion treatment.
- 社団法人日本循環器学会の論文
- 2007-03-20
著者
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LEE Sang
Department of Pulmonary and Critical Care Medicine, Gachon University, Gil Medical Center
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Kim Duk-kyung
韓国
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Kim Duk-kyung
Department Of Radiology Samsung Medical Center Sungkyunkwan University School Of Medicine
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Lim Seong
Department Of Medicine Samsung Medical Center Sungkyunkwan University School Of Medicine
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Choi Jin-ho
Sungkyunkwan University School Of Medicine Samsung Medical Center Department Of Emergency Medicine
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Choi Jin-Ho
Department of Emergency Medicine, Cardiac and Vascular Center, Cardiovascular Imaging Center, Samsun
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Gwon Hyeon-Cheol
Department of Medicine, Cardiac and Vascular Center, Cardiovascular Imaging Center, Samsung Medical
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Lee Wang-soo
Department Of Medicine Samsung Medical Center Sungkyunkwan University School Of Medicine
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Kim Duk-kyung
Department Of Anesthesiology And Pain Medicine Konkuk University School Of Medicine
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Lee Sang-Chol
Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center
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Jeon Eun-Seok
Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center
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Lee Sang
Department Of Advanced Materials Science And Engineering Mokpo National University
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Jeon Eun-seok
韓国
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Choi Jinoh
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
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Rhee Il
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
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Choe Yeon
Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicin
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Kim Dae
Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Med
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Suh Wonhee
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine
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Kim Dae
Samsung Biomedical Research Institute Samsung Medical Center Sungkyunkwan University School Of Medic
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Rhee Il
Department Of Medicine Samsung Medical Center Sungkyunkwan University School Of Medicine
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Lee Sang-chol
Samsung Medical Center Sungkyunkwan University School Of Medicine Republic Of Korea
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Jeon Eun-seok
Department Of Medicine Sungkyunkwan University School Of Medicine Cardiac And Vascular Center Samsun
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Choi Jae
Department Of Medicine Sungkyunkwan University School Of Medicine Samsung Medical Center
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Choe Yeon
Department Of Laboratory Medicine Samsung Medical Center Sungkyunkwan University School Of Medicine
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Suh Wonhee
Department Of Radiology Samsung Medical Center Sungkyunkwan University School Of Medicine
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Choi Jin-oh
Samsung Medical Center Sungkyunkwan University School Of Medicine Republic Of Korea
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Choi Jin-ho
Department Of Computer Engineering Pusan University Of Foreign Studies
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Lee Sahng
Eulji Medical Center Eulji University
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Kim Dae
Samsung Biomedical Research Institute
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Gwon Hyeon-cheol
Division Of Cardiology Department Of Medicine Samsung Medical Center Sungkyunkwan University School
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Gwon Hyeon-cheol
Department Of Medicine Cardiac And Vascular Center Cardiovascular Imaging Center Samsung Medical Cen
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Choi Jin-oh
Cardiovascular Imaging Center Cardiac And Vascular Center Samsung Medical Center Sungkyunkwan Univer
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Lee Sang-chol
Cardiovascular Imaging Center Cardiac And Vascular Center Samsung Medical Center Sungkyunkwan Univer
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Lee Sang-chol
Division Of Cardiology Department Of Medicine Cardiovascular Imaging Center Samsung Medical Center Sungkyunkwan University School Of Medicine
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LEE Sang
Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University
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Jeon Eun-Seok
Department of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea
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