Sesquiterpene Furan Compound CJ-01, a Novel Chitin Synthase 2 Inhibitor from Chloranthus japonicus SIEB.(Pharmacognosy)

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概要

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• A novel sesquiterpene furan compound CJ-01 was isolated from the methanol extract of the whole plant of Chloranthus japonicus SIEB. by monitoring the inhibitory activity of chitin synthase 2 from Saccharomyces cerevisiae. Based on spectroscopic analysis, the structure of compound CJ-01 was determined as 3,4,8a-trimethyl-4a,7,8,8a-tetrahydro-4a-naphto[2,3-b]furan-9-one. The compound inhibited chitin synthase 2 of Saccharomyces cerevisiae in a dose-dependent manner with an IC_<50> of 39.6 μg/ml, whereas it exhibited no inhibitory activities against chitin synthase 1 and 3 of S. cerevisiae up to 280 μg/ml. CJ-01 has 1.7-fold stronger inhibitory activity than polyoxin D (IC_<50>=70 μg/ml), a well-known chitin synthase inhibitor. These results indicate that the compound is a specific inhibitor of chitin synthase 2 from S. cerevisiae. In addition, CJ-01 showed antifungal activities against various human and phytopathogenic fungi. Therefore, the compound might be an interesting lead to develop effective antifungal agents.

• 公益社団法人日本薬学会の論文
• 2008-05-01

著者

• LEE Sang

  Department of Pulmonary and Critical Care Medicine, Gachon University, Gil Medical Center

• Moon Jae

  Korea Research Institute Of Bioscience And Biotechnology

• Kim Sun

  Korea Research Institute Of Bioscience And Biotechnology

• Hwang Eui

  Kt&g Central Research Institute

• Lee Sang

  Department Of Food Science And Technology Kyungpook National University

• Park Ki

  Korea Food & Drug Administration

• YUN Bong

  Korea Research Institute of Bioscience and Biotechnology

• KIM Sung

  Korea Food Research Institute

• Lee Sang

  Department Of Advanced Materials Science And Engineering Mokpo National University

• Park Ki

  Korea Research Institute Of Bioscience And Biotechnology

• YIM Nam

  Korea Research Institute of Bioscience and Biotechnology

• HWANG Eui

  KT&G Central Research Institute

• SUNG Nack

  Department of Agricultural Chemistry, Chungnam National University

• Sung Nack

  Department Of Agricultural Chemistry Chungnam National University

• LEE Sang

  Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University

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