Folium mori Increases Cell Proliferation and Neuropeptide Y Expression in Dentate Gyrus of Streptozotocin-Induced Diabetic Rats
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概要
- 論文の詳細を見る
The possibility has been raised that Folium mori is clinically effective for the treatment and prevention of diabetes. In the present study, the effects of Folium mori on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyms of rats with streptozotocin (STZ)-induced diabetes were investigated by 5-bromo-2'- deoxyuridine (BrdU) immunohistochemistry and NPY immunohistochemistry. In rats with STZ-induced diabetes, cell proliferation and NPY expression in the dentate gyrus were suppressed, and treatment with Folium mori was shown to increase new cell formation and NPY expression in the dentate gyrus in both normal rats and those with STZ-induced diabetes. In light of previous studies, this result appears to indicate that increased expression of NPY in the dentate gyrus induced by treatment with Folium mori is associated with the observed effect of Folium mori extract on cell proliferation. Based on the present results, it is suggested that Folium mori treatment may aid in the recovery from the central nervous system complications of diabetes mellitus.
- 社団法人日本薬学会の論文
- 2003-04-01
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
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CHANG Hyun-Kyung
Department of Physiology, College of Medicine, Kyung Hee University
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LEE Taeck-Hyun
Department of Physiology, College of Medicine, Kyung Hee University
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Hong
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
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LIM Baek-Vin
Department of Physiology, College of Medicine, Kyung Hee University
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CHANG Hyum-Kyung
Department of Physiology, College of Medicine, Kyitng Hee University
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LEE Taeck-Hyum
Department of Physiology, College of Medicine, Kyitng Hee University
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JUNG Chang-Young
Department of Physiology. College of Oriental Medicine, Kyungwon University
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LEE Choong-Yeol
Department of Physiology. College of Oriental Medicine, Kyungwon University
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Kim Chang-ju
韓国
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Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Ee-hwa
韓国
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Kim H
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Lee T‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Lee Taeck-hyun
韓国
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
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Chang H‐k
Department Of Physiology College Of Medicine Kyung Hee University
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Lim Baek-vin
Department Of Physiology College Of Medicine Kyung Hee University
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Chang Hyum-kyung
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Hong
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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Lee Choong-yeol
Department Of Physiology. College Of Oriental Medicine Kyungwon University
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Kim Hong
Department Of Chemistry Advanced Materials Chemistry Research Center Korea University
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Kim H
Graduate School Of East-west Medical Science Kyung Hee University
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Jung Chang-young
Department Of Physiology. College Of Oriental Medicine Kyungwon University
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Kim Hong
Department of Applied Sciences, Korea Maritime University, Busan 606-791, Korea
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