Bee Venom Induces Apoptosis and Inhibits Expression of Cyclooxygenase-2 mRNA in Human Lung Cancer Cell Line NCI-H1299
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概要
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To investigate whether bee venom (BV) induces apoptosis, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, terminal deoxynucleotidyl transferase- mediated dUTP nick end-labeling assay, 4,6-diamidino-2-phenylindole staining, flow cytometric analysis, and DNA fragmentation assay were performed on NCI-H1299 lung cancer cells treated with BV. Through morphological and biochemical analyses, it was demonstrated that NCI-H1299 cells treated with BV exhibit several features of apoptosis. In addition, reverse transcription-polymerase chain reaction and prostaglandin E2 (PGE2) immunoassay were performed to verify whether BV possesses an inhibitory effect on the expression of cyclooxygenase (COX) and PGE2 synthesis. Expression of COX-2 mRNA and synthesis of PGE2 were inhibited by BV. These results suggest the possibility that BV may exert an anti-tumor effect on human lung cancer.
- 社団法人 日本薬理学会の論文
- 2003-02-01
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
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LIM Sabina
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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HAN Seung-Moo
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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PARK Hi-Joon
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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SHIN Insop
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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LEE Ji-Suk
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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KIM Kyoung-Ah
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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Lee Jong-soo
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Ee-hwa
韓国
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Lee J‐s
Department Of Physiology College Of Medicine Kyung Hee University
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Shin H‐d
College Of Nursing Science Kyung Hee University
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Park H‐j
Korea Univ. Seoul Kor
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Lee Jong-sung
Biotoxtech Co. Ltd.
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Lee Jong-sung
韓国
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Kyung-ah
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Han Seung-moo
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Shin Insop
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Lim Sabina
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Lee J
Kyung Hee Univ. Seoul Kor
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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Park Hi-joon
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Lee Ji-suk
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Lee J
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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