Modulation of Corydalis tuber on Glycine-Induced Ion Current in Acutely Dissociated Rat Periaqueductal Gray Neurons(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Traditionally, Corydalis tuber has been used for the control of pain including headache, stomachache, and neuralgia. In the present study, modulation of the Corydalis tuber on glycine-activated ion current in the acutely dissociated periaqueductal gray (PAG) neurons was studied by a nystatin-perforated patch-clamp technique. High concentrations of Corydalis tuber elicited ion current, which was suppressed by strychnine application, while low concentrations of Corydalis tuber reduced glycine-induced ion current in the PAG neurons. Inhibitory action of Corydalis tuber on glycine-activated ion current was partially abolished by treatment with naltrexone, a non-selective opioid antagonist. Application of N-methylmalemide (NEM), a sulfhydryl alkylating agent, also partially abolished the inhibitory action of Corydalis tuber on glycine-activated ion current in the PAG neurons. These results suggest that the inhibitory effect of Corydalis tuber on glycine-activated ion current in the PAG neurons is one of the analgesic mechanisms of the Corydalis tuber.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
-
Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim C‐j
Kyung Hee Univ. Seoul Kor
-
CHANG Hyun-Kyung
Department of Physiology, College of Medicine, Kyung Hee University
-
SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
-
KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
-
SHIN Mal-Soon
Department of Physiology, College of Medicine, Kyung Hee University
-
Kim Chang-ju
韓国
-
LEE Jae-Dong
Department of Microbiology, College of Natural Sciences, Pusan National University
-
Lee J‐s
Department Of Physiology College Of Medicine Kyung Hee University
-
Lee Jong-sung
Biotoxtech Co. Ltd.
-
Lee J‐d
Department Of Microbiology College Of Natural Sciences Pusan National University
-
Lee Jun
Department Of Pharmacy College Of Pharmacy Pusan National University
-
Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
-
Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
-
Chang H‐k
Department Of Physiology College Of Medicine Kyung Hee University
-
Choi Do-young
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University
-
Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
-
Lee Jun-sik
Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine
-
CHEONG Byung-Shik
Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung Hee University
-
CHO Nam-Hun
Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung Hee University
-
Lee Jun-sik
Department Of Microbiology College Of Natural Sciences Pusan National University
-
Lee J
Kyung Hee Univ. Seoul Kor
-
Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
-
Cho Nam-hun
Department Of Acupuncture And Moxibustion College Of Oriental Medicine Kyung Hee University
-
Lee Jae-dong
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University
-
Cheong Byung-shik
Department Of Acupuncture And Moxibustion College Of Oriental Medicine Kyung Hee University
関連論文
- Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring
- Maternal Alcohol Administration Suppresses Expression of Nitric Oxide Synthase in the Hippocampus of Offspring Rats
- Effects of Corydalis Tuber on synthesis of NO and PGE_2 in murine macrophage RAW 264.7 cells stimulated by LPS(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Scie
- Atractylodes japonica Suppresses Lipopolysaccharide-Stimulated Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Macrophages (Pharmacology)
- Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells (Pharmacology)
- Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
- Folium mori Increases Cell Proliferation and Neuropeptide Y Expression in Dentate Gyrus of Streptozotocin-Induced Diabetic Rats
- Bee Venom Induces Apoptosis and Inhibits Expression of Cyclooxygenase-2 mRNA in Human Lung Cancer Cell Line NCI-H1299
- Effects of Paeonia radix on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in the Dorsal Raphe of Exercised Rats
- Effect of Puerariae radix on c-Fos Expression in Hippocampus of Alcohol-Intoxicated Juvenile Rats(Pharmacology)
- A dministration of Folium mori Extract Decreases Nitric Oxide Synthase Expression in the Hypothalamus of Streptozotocin-Induced Diabetic Rats
- Effects of Puerariae radix on Cell Proliferation and Nitric Oxide Synthase Expression in Dentate Gyrus of Alcohol-Intoxicated Sprague-Dawley Rats
- Serotonin Induces Apoptosis in PGT-β Pineal Gland Tumor Cells
- Effects of Corydalis Tuber on synthesis of NO and PGE_2 in murine macrophage RAW 264.7 cells stimulated by LPS(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Scie
- Curcumin Decreases Binding of Shiga-Like Toxin-1B on Human Intestinal Epithelial Cell Line HT29 Stimulated with TNF-α and IL-1β : Suppression of p38, JNK and NF-kB p65 as Potential Targets(Miscellaneous)
- Alleviation of Experimental Septic Shock in Mice by Acidic Polysaccharide Isolated from the Medicinal Mushroom Phellinus linteus(Medicinal Chemistry)
- Anti-inflammatory and Anti-nociceptive Effects of the Methanol Extract of Fomes fomentarius(Pharmacognosy)
- Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols
- Nitric Oxide Induces Apoptosis in Mouse C2C12 Myoblast Cells
- Ginseng radix Increases Cell Proliferation in Dentate Gyrus of Rats with Streptozotocin-Induced Diabetes
- Protective Effects of Puerariae flos Against Ethanol-Induced Apoptosis on Human Neuroblastoma Cell Line SK-N-MC
- Protective Effect of (4-Methoxybenzylidene)-(3-methoxynophenyl)amine against Neuronal Cell Death Induced by Oxygen and Glucose Deprivation in Rat Organotypic Hippocampal Slice Culture(Medicinal Chemistry)
- Bcl-2 and Caspase-3 Are Major Regulators in Agaricus blazei-Induced Human Leukemic U937 Cell Apoptosis through Dephoshorylation of Akt(Pharmacology)
- Proteoglycan Isolated from Phellinus linteus Induces Toll-Like Receptors 2- and 4-Mediated Maturation of Murine Dendritic Cells via Activation of ERK, p38, and NF-κB(Miscellaneous)
- Harpagophytum procumbens Suppresses Lipopolysaccharide-Stimulated Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Fibroblast Cell Line L929
- Protective Effect of Gabapentin on N-Methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampal CA1 Neurons
- Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers
- Maternal swimming during pregnancy enhances short-term memory and neurogenesis in the hippocampus of rat pups
- Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats
- Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro(Miscellaneous)
- Daidzein Activates Choline Acetyltransferase from MC-IXC Cells and Improves Drug-Induced Amnesia
- Effects of Oleamide on Choline Acetyltransferase and Cognitive Activities(Food & Nutrition Science)
- The Efficacy and Mechanism Action of RvCSd, a New Herbal Agent, on Immune Suppression and Cartilage Protection in a Mouse Model of Rheumatoid Arthritis
- Therapeutic Effect of Siegesbeckia pubescens on Cartilage Protection in a Rabbit Collagenase-Induced Model of Osteoarthritis
- Effect of Aralia cordata Extracts on Cartilage Protection and Apoptosis Inhibition(Pharmacognosy)
- Effect of Betula platyphylla var. japonica on Proteoglycan Release, Type II Collagen Degradation, and Matrix Metalloproteinase Expression in Rabbit Articular Cartilage Explants(Pharmacognosy)
- Effects of 2-bromopropane on the female reproductive function in Sprague-Dawley rats.
- Sphingosine kinase inhibitor suppresses a T_h1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells
- Case of dystrophic calcinosis cutis in epidermal cyst arising from verrucous epidermal nevus
- Immunohistochemical characterization of cutaneous drug eruptions by STI571
- Oral Administration of Proteoglycan Isolated from Phellinus linteus in the Prevention and Treatment of Collagen-Induced Arthritis in Mice
- Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
- Geniposide from Gardenia jasminoides Attenuates Neuronal Cell Death in Oxygen and Glucose Deprivation-Exposed Rat Hippocampal Slice Culture(Pharmacognosy)
- Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
- Partial Characterization and Immunostimulatory Effect of a Novel Polysaccharide-Protein Complex Extracted from Phellinus linteus
- Effect of increases in tumor volume after neoadjuvant chemotherapy on the outcome of stage II osteosarcoma regardless of histological response
- Amygdalin Induces Apoptosis through Regulation of Bax and Bcl-2 Expressions in Human DU145 and LNCaP Prostate Cancer Cells(Pharmacology)
- Modulation of Corydalis tuber on Glycine-Induced Ion Current in Acutely Dissociated Rat Periaqueductal Gray Neurons(Pharmacology)
- Antinociceptive Effect of Amygdalin Isolated from Prunus armeniaca on Formalin-Induced Pain in Rats(Pharmacognosy)
- Armeniacae semen Extract Suppresses Lipopolysaccharide-Induced Expressions of Cycloosygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells(Pharmacology)
- Effect of Ginseng radix on c-Fos Expression in the Hippocampus of Streptozotocin-Induced Diabetic Rats
- Evaluation of Genotoxity with Various Crude Drugs(Mutagenicity, Proceedings of the 32nd Annual Meeting)
- ORAL SINGLE- AND REPEATED-DOSE TOXICITY STUDIES ON GERANTI BIO-GE YEAST^[○!R], ORGANIC GERMANIUM FORTIFIED YEASTS, IN DOGS
- ORAL SINGLE- AND REPEATED-DOSE TOXICITY STUDIES ON GERANTI BIO-GE YEAST^[○!R], ORGANIC GERMANIUM FORTIFIED YEASTS, IN RATS
- Transport of Charge Carriers in HgTe/CdTe Core-Shell Nanoparticle Film
- Vascular Relaxation by the Methanol Extract of Sorbus Cortex via NO-cGMP Pathway(Pharmacognosy)
- Effects of Polyvinyl Alcohol on the Rheological Behavior and Phase Stability of Aqueous Silica Suspensions
- Characteristic of TiNi Shape Memory Alloy Fiber Reinforced 6061 Aluminum Matrix Composite by Using FEA and Experiment
- Activation Effects of Allium Tuberosum Rottl. on Choline Acetyltransferase
- Uncaria rhynchophylla Induces Angiogenesis in Vitro and in Vivo(Pharmacognosy)
- PRESSURE DROP THOUGH PACKED BED
- $p$-QUASIHYPONORMAL, CLASS A($s, t$)作用素のスペクトルについて (作用素不等式に関わる最近の話題)
- ALGEBRAICALLY PARANORMAL OPERATOR と WEYL の定理 (作用素の構造と関連する最近の話題)
- Objective interpretation of severity of SLS induced edema by stereoimaging
- Ginseng radix Increases Cell Proliferation in Dentate Gyrus of Rats with Streptozotocin-Induced Diabetes
- Byte Merging Inter-Row Interleaving Scheme for the Error Control of High-Density Digital Verstile Disk
- Comuparison of Breakdown Behavior in Electron-Irradiated and Proton-Irradiated Silicon pn Junctions
- Protective Effects of Kaempferol (3,4′,5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
- Activation Effects of Allium Tuberosum Rottl. on Choline Acetyltransferase
- Protective Effects of Kaempferol (3,4',5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
- Dendritic Cell-Tumor Fusion Vaccine Prevents Tumor Growth in Vivo
- Tegafur-induced hyperpigmentation of the tongue
- Effects of Phellinus linteus Administration on Serotonin Synthesis in the Brain and Expression of Monocarboxylate Transporters in the Muscle during Exhaustive Exercise in Rats
- Effects of Methoxsalen from Poncirus trifoliata on Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment
- Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal-separated rat pups
- Improved Degradation and Recovery Characteristics of SiGe p-Channel Metal--Oxide--Semiconductor Field-Effect Transistors under Negative-Bias Temperature Stress
- SCTP with Explicit Freeze and Melt Notification for Delay Tolerant Applications