Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro(Miscellaneous)

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概要

• 論文の詳細を見る

• Water extract (WE) of Cordyceps militaris has been reported to produce antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not been known. In this study, we investigated whether water extract of C. militaris induces the phenotypic and functional maturation of dendritic cells (DC). It profoundly increased CD40, CD54, CD80, CD86, and MHC class II expression in murine bone marrow (BM)-derived myeloid DC. Endocytosis was assessed by the uptake of FITC-dextran and FITC-albumin. The ability of unstimulated DC (UT-DC) to uptake dextran and albumin was higher than that of WE- or LPS-stimulated DC (LPS-DC). Also, UT-DC secreted a low concentration of IL-12, while WE- or LPS-DC secreted higher levels of IL-12 than UT-DC. WE not only formed morphologically mature DC and clusters, but also induced predominantly functional maturation. Moreover, WE is shown to promote the cytotoxicity of specific-cytotoxic T lymphocyte (CTL) induced by DC which were pulsed with P815 tumor-lysate during the stage of antigen presentation. These results suggest that DC maturation by WE can play a critical role in the improvement of the immunoregulatory function in patients with impaired host defense.

• 社団法人日本薬学会の論文
• 2006-02-01

著者

• Park Yeong-min

  Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine

• Park Yeong-min

  Dep. Of Microbiology And Immunology And National Res. Lab. Of Dendritic Cell Differentiation & R

• Choi Byung

  韓国

• PARK Yeong-Min

  Department of Microbiology & Immunology, and National Research Laboratory of Dendritic Cell Differen

• Lee Kyu-sub

  Dep. Of Obstetrics And Gynecology Pusan National Univ. Coll. Of Medicine

• Choi Yung

  韓国

• Lee J‐d

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Jeong Young-il

  Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia

• Choi Byung

  Division Of Applied Life Science Gyeongsang National University

• Kim Gi-young

  韓国

• Kim Gi-young

  Faculty Of Applied Marine Science Cheju National University

• Lee Jun

  Department Of Pharmacy College Of Pharmacy Pusan National University

• Heo Moon-soo

  School Of Applied Marine Science College Of Ocean Science Cheju National University

• KIM Gi-Young

  School of Applied Marine Science, College of Ocean Science, Cheju National University

• KO Woo-Shin

  Clinical Research Center of Oriental Medicine

• LEE Jae-Yoon

  Department of Oriental Medicine, Dongeui University College of Oriental Medicine

• LEE Jeong-Ok

  Department of Microbiology, College of Natural Sciences, Pusan National University

• RYU Chung-Ho

  Department of Microbiology, College of Natural Sciences, Pusan National University

• JEONG Young-Ki

  Department of Microbiology, Dongeui University

• LEE Kyeong-Jun

  School of Applied Marine Science, College of Ocean Science, Cheju National University

• CHOI Kwang-Sik

  School of Applied Marine Science, College of Ocean Science, Cheju National University

• CHOI Yung

  Division of Applied Life Science, Gyeongsang National University

• Lee Jun-sik

  Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine

• Park Yeong-min

  Department Of Microbiology & Immunology And National Research Laboratory Of Dendritic Cell Diffe

• Kim Yong

  Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia

• Lee Jun-sik

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Choi Kwang-sik

  School Of Applied Marine Science Cheju National University

• Ryu Chung-ho

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Lee Jae-dong

  Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University

• Lee Jae-yoon

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Jeong Young-ki

  Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia

• Park Young-mi

  Department Of Microbiology And Immunology And National Research Laboratory Of Dendritic Cell Differe

• Kim Gi-pimg

  School of Applied Marine Science, College of Ocean Science, Cheju National University

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