Biotransformation of Korean Panax ginseng by Pectinex(Miscellaneous)

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概要

• 論文の詳細を見る

• Ginsenosides comprise the major component of ginseng exhibit various types of biological activity, including antiinflammatory and antitumor effects. In these pharmacological actions, it is thought that these activities are carried out by the metabolites of ginsenosides metabolized by human intestinal microflora. It has also been reported that their clinical efficacy varies with the hydrolyzing potential of the components of the intestinal microflora. We tried to develop a process for metabolizing ginsenosides to compound K using food-grade enzymes, which can be used commercially. Among these, Pectinex proved to be the most effective mediator of the catabolism of ginsenosides to compound K. The optimal conditions for this biotransformation were determined to be as follows: 10 to 15% rootlet ginseng, pH 5, 50℃, and 2 to 3 d of incubation, to yield 20.0mg of compound K/g of rootlet ginseng. We suggest that the metabolism of ginseng to compound K in the presence of Pectinex has many advantages over previous methods, in respects of use of raw, non-extracted rootlet ginseng, which do not require more organic solvents and evaporation apparatus. Potential metabolites PG1, PG2, PG3, and PG4 were detected in Pectinex-treated rootlet ginseng using by TLC and HPLC and, among them, PG4 was identified as compound K by TLC, HPLC, and MS. Additional studies will be carried out to determine the structure of these metabolites of ginseng and to understand the relationship between their structures and activities.

• 公益社団法人日本薬学会の論文
• 2006-12-01

著者

• KIM Yeong-Jin

  Department of Neurosurgery, Osaka Police Hospital

• Ahn Soon-cheol

  Department Of Microbiology & Immunology And National Research Laboratory Of Dendritic Cell Diffe

• PARK Yeong-Min

  Department of Microbiology & Immunology, and National Research Laboratory of Dendritic Cell Differen

• Kim Yeong-jin

  Department Of Microbiology And Immunology Pusan National University School Of Medicine

• Ahn Soon-cheol

  Department Of Microbiology And Immunology Pusan National University School Of Medicine:medical Resea

• PARK Cheon-Seok

  Department of Food Science and Technology, Kyunghee University

• Lee Sun-yi

  Department Of Microbiology And Immunology Pusan National University School Of Medicine

• KIM Bo-Hye

  Department of Microbiology and Immunology, Pusan National University School of Medicine

• CHO Hyo-Jin

  Department of Microbiology and Immunology, Pusan National University School of Medicine

• YOU Sun-Nyoung

  Department of Microbiology and Immunology, Pusan National University School of Medicine

• LEE Jae-Kwon

  Department of Food Science and Biotechnology, Kyonggi University

• BAIK Moo-Yeol

  Department of Food Science and Technology, Institute of Life Resource Science, Kyunghee University

• Park Yeong-min

  Department Of Microbiology And Immunology & National Research Laboratory Of Dendritic Cell Diffe

• Kim Bo-hye

  Department Of Microbiology And Immunology Pusan National University School Of Medicine

• You Sun-nyoung

  Department Of Microbiology And Immunology Pusan National University School Of Medicine

• Lee Jae-kwon

  Department Of Food Science And Biotechnology Kyonggi University

• Kim Bo-hye

  Department Of Chemistry And Institute Of Basic Science Chonnam National University

• Cho Hyo-jin

  Department Of Microbiology And Immunology Pusan National University School Of Medicine

• Baik Moo-yeol

  Department Of Food Science And Technology Institute Of Life Resource Science Kyunghee University

• Kim Yeong-jin

  Department Of Dermatology Kosin University College Of Medicine

• Park Cheon-seok

  Department Of Food Science And Technology Institute Of Life Resource Science Kyunghee University

• Baik Moo-Yeol

  Department of Food Science and Biotechnology, Kyung Hee University

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