Curcumin Decreases Binding of Shiga-Like Toxin-1B on Human Intestinal Epithelial Cell Line HT29 Stimulated with TNF-α and IL-1β : Suppression of p38, JNK and NF-kB p65 as Potential Targets(Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
Intestinal epithelial cells (IECs) have been known to produce galactose-α1,4-galactose-β1,4-glucose ceramide (Gb3) which plays a pivotal role in the mucosal immune response. In particular, Shiga-like toxins (Stx) can induce apoptosis of IECs in the development of hemolytic uremic syndrome (HUS) through binding on Gb3. Therefore, it has been hypothesized that down-regulation of Gb3 (or binding of Stx) prevents Stx from damaging in IECs. This study investigated whether curcumin, having various biological properties such as being anti-bacterial, anti-viral and anti-cancer, could decrease binding of Stx and the related signal pathway. Curcumin significantly inhibited the binding of Stx and the production of Gb3 synthase (GalT6) mRNA in HT29 IECs stimulated with TNF-α and IL-1β. Additionally, curcumin was able to inhibit mitogen-activated protein kinases (MAPKs), such as p38 and JNK, but not ERK1/2, degradation of IκB or translocation of NF-κB p65. Furthermore, curcumin significantly attenuated Stx-1 induced cell death and IL-8 expression. In summary, these data link Gb3 expression in HT29 cells stimulated with TNF-α and IL-1β and suggest that blocking of Stx-binding by curcumin may prevent the Stx-associated HUS.
- 社団法人日本薬学会の論文
- 2006-07-01
著者
-
Park Yeong-min
Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine
-
Park Yeong-min
Dep. Of Microbiology And Immunology And National Res. Lab. Of Dendritic Cell Differentiation & R
-
Ahn Soon-cheol
韓国
-
Ahn Soon-cheol
Department Of Microbiology & Immunology And National Research Laboratory Of Dendritic Cell Diffe
-
MOON Dong-Oh
Faculty of Applied Marine Science, Cheju National University
-
JIN Cheng-Yun
Department of Microbiology, College of Natural Sciences, Pusan National University
-
LEE Jae-Dong
Department of Microbiology, College of Natural Sciences, Pusan National University
-
CHOI Yung
Department of Oriental Medicine, Dongeui University College of Oriental Medicine
-
LEE Chang-Min
Department of Microbiology & Immunology, and National Research Laboratory of Dendritic Cell Differen
-
JEONG Sang-Cheol
Faculty of Applied Marine Science, Cheju National University
-
PARK Yeong-Min
Department of Microbiology & Immunology, and National Research Laboratory of Dendritic Cell Differen
-
KIM Gi-Young
Faculty of Applied Marine Science, Cheju National University
-
Choi Yung
韓国
-
Moon Dong-oh
韓国
-
Lee J‐d
Department Of Microbiology College Of Natural Sciences Pusan National University
-
Moon Dong-oh
Faculty Of Applied Marine Science Cheju National University
-
Kim Gi-young
韓国
-
Kim Gi-young
Faculty Of Applied Marine Science Cheju National University
-
Lee Jun
Department Of Pharmacy College Of Pharmacy Pusan National University
-
Lee Chang-min
韓国
-
Lee Jun-sik
Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine
-
Park Yeong-min
Department Of Microbiology & Immunology And National Research Laboratory Of Dendritic Cell Diffe
-
Lee Jun-sik
Department Of Microbiology College Of Natural Sciences Pusan National University
-
Lee Chang-min
Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia
-
Choi Yung
Department Of Biochemistry Dongeui University College Of Oriental Medicine
-
Lee Jae-dong
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University
-
Jin Cheng-yun
Department Of Microbiology College Of Natural Sciences Pusan National University
-
Park Young-mi
Department Of Microbiology And Immunology And National Research Laboratory Of Dendritic Cell Differe
-
Jeong Sang-cheol
Faculty Of Applied Marine Science Cheju National University
関連論文
- Effects of Paeonia radix on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in the Dorsal Raphe of Exercised Rats
- Curcumin Decreases Binding of Shiga-Like Toxin-1B on Human Intestinal Epithelial Cell Line HT29 Stimulated with TNF-α and IL-1β : Suppression of p38, JNK and NF-kB p65 as Potential Targets(Miscellaneous)
- Alleviation of Experimental Septic Shock in Mice by Acidic Polysaccharide Isolated from the Medicinal Mushroom Phellinus linteus(Medicinal Chemistry)
- Preventive Effect of Ginkgo biloba Extract (GBB) on the Lipopolysaccharide-Induced Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 via Suppression of Nuclear Factor-κB in RAW 264.7 Cells(Pharmacognosy)
- Methanol Extract of Xanthium strumarium L. Possesses Anti-inflammatory and Anti-nociceptive Activities(Pharmacognosy)
- Anti-inflammatory and Anti-nociceptive Effects of the Methanol Extract of Fomes fomentarius(Pharmacognosy)
- Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols
- Inhibitory Effects of Agaricus blazei on Mast Cell-Mediated Anaphylaxis-Like Reactions(Pharmacology)
- Bcl-2 and Caspase-3 Are Major Regulators in Agaricus blazei-Induced Human Leukemic U937 Cell Apoptosis through Dephoshorylation of Akt(Pharmacology)
- Proteoglycan Isolated from Phellinus linteus Induces Toll-Like Receptors 2- and 4-Mediated Maturation of Murine Dendritic Cells via Activation of ERK, p38, and NF-κB(Miscellaneous)
- Protective Effect of Gabapentin on N-Methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampal CA1 Neurons
- Maternal swimming during pregnancy enhances short-term memory and neurogenesis in the hippocampus of rat pups
- Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro(Miscellaneous)
- The Guanylyl Cyclase Activator YC-1 Directly Inhibits the Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells
- The Efficacy and Mechanism Action of RvCSd, a New Herbal Agent, on Immune Suppression and Cartilage Protection in a Mouse Model of Rheumatoid Arthritis
- Therapeutic Effect of Siegesbeckia pubescens on Cartilage Protection in a Rabbit Collagenase-Induced Model of Osteoarthritis
- Effect of Aralia cordata Extracts on Cartilage Protection and Apoptosis Inhibition(Pharmacognosy)
- Effect of Betula platyphylla var. japonica on Proteoglycan Release, Type II Collagen Degradation, and Matrix Metalloproteinase Expression in Rabbit Articular Cartilage Explants(Pharmacognosy)
- Effects of 2-bromopropane on the female reproductive function in Sprague-Dawley rats.
- Sphingosine kinase inhibitor suppresses a T_h1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells
- β-Sitosterol Induces Anti-proliferation and Apoptosis in Human Leukemic U937 Cells through Activation of Caspase-3 and Induction of Bax/Bcl-2 Ratio(Miscellaneous)
- Case of dystrophic calcinosis cutis in epidermal cyst arising from verrucous epidermal nevus
- Immunohistochemical characterization of cutaneous drug eruptions by STI571
- Oral Administration of Proteoglycan Isolated from Phellinus linteus in the Prevention and Treatment of Collagen-Induced Arthritis in Mice
- Biotransformation of Korean Panax ginseng by Pectinex(Miscellaneous)
- Dendritic Cell-Tumor Fusion Vaccine Prevents Tumor Growth in Vivo
- Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
- Partial Characterization and Immunostimulatory Effect of a Novel Polysaccharide-Protein Complex Extracted from Phellinus linteus
- Effect of increases in tumor volume after neoadjuvant chemotherapy on the outcome of stage II osteosarcoma regardless of histological response
- Amygdalin Induces Apoptosis through Regulation of Bax and Bcl-2 Expressions in Human DU145 and LNCaP Prostate Cancer Cells(Pharmacology)
- Modulation of Corydalis tuber on Glycine-Induced Ion Current in Acutely Dissociated Rat Periaqueductal Gray Neurons(Pharmacology)
- Transport of Charge Carriers in HgTe/CdTe Core-Shell Nanoparticle Film
- Vascular Relaxation by the Methanol Extract of Sorbus Cortex via NO-cGMP Pathway(Pharmacognosy)
- Effects of Polyvinyl Alcohol on the Rheological Behavior and Phase Stability of Aqueous Silica Suspensions
- Characteristic of TiNi Shape Memory Alloy Fiber Reinforced 6061 Aluminum Matrix Composite by Using FEA and Experiment
- CYP724B2 and CYP90B3 Function in the Early C-22 Hydroxylation Steps of Brassinosteroid Biosynthetic Pathway in Tomato
- Uncaria rhynchophylla Induces Angiogenesis in Vitro and in Vivo(Pharmacognosy)
- PRESSURE DROP THOUGH PACKED BED
- Fraxinellone Inhibits Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression by Negatively Regulating Nuclear Factor-kappa B in RAW 264.7 Macrophages Cells
- $p$-QUASIHYPONORMAL, CLASS A($s, t$)作用素のスペクトルについて (作用素不等式に関わる最近の話題)
- ALGEBRAICALLY PARANORMAL OPERATOR と WEYL の定理 (作用素の構造と関連する最近の話題)
- Objective interpretation of severity of SLS induced edema by stereoimaging
- Byte Merging Inter-Row Interleaving Scheme for the Error Control of High-Density Digital Verstile Disk
- Comuparison of Breakdown Behavior in Electron-Irradiated and Proton-Irradiated Silicon pn Junctions
- Dendritic Cell-Tumor Fusion Vaccine Prevents Tumor Growth in Vivo
- Tegafur-induced hyperpigmentation of the tongue
- The Guanylyl Cyclase Activator YC-1 Directly Inhibits the Voltage-Dependent K^+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells
- Induction of Egr-1 Is Associated with Anti-Metastatic and Anti-Invasive Ability of β-Lapachone in Human Hepatocarcinoma Cells
- p53-independent Induction of p21 (WAF1/CIP1), Reduction of Cyclin B1 and G2/M Arrest by the Isoflavone Genistein in Human Prostate Carcinoma Cells
- Calcium Channel Inhibitor, Verapamil, Inhibits the Voltage-Dependent K+ Channels in Rabbit Coronary Smooth Muscle Cells
- SCTP with Explicit Freeze and Melt Notification for Delay Tolerant Applications