ORAL SINGLE- AND REPEATED-DOSE TOXICITY STUDIES ON GERANTI BIO-GE YEAST^[○!R], ORGANIC GERMANIUM FORTIFIED YEASTS, IN DOGS
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概要
- 論文の詳細を見る
Single- and 13-week repeated-dose toxicities of Geranti Bio-Ge Yeast^[○!R], organic germanium fortified yeasts, were investigated in dogs Both sexes of Beagle dogs were orally administered once at a dose of 2,000 mg/kg in single-dose toxicity or daily for 13 weeks at doses of 500, 1,000 or 2,000 mg/kg in repeated-dose toxicity tests In single-dose toxicity test, no animal dead, moribund, or showing clinical signs or changes in body weight gain was found In repeated-dose toxicity study, there were no considerable changes in ophthalmoscopy and urinalysis Several alterations were observed in electrocardiography, hematology and blood biochemistry, including heart rate, R-R interval, QT correcting, reticulocytes, activated partial thromboplastin time and albumin/globulin ratio in only male dogs, but not in females, administered with Geranti Bio-Ge Yeast^[○!R] in a dose-independent manner In gross findings, several cases of abnormal findings were observed in both control and treatment groups, showing diffuse dark brown to black discoloration of liver, in a dose-independent manner In microscopic examination, mild lesions, including cholestasis and inflammatory cell foci in liver, kidneys and prostate, were found sporadically in both control and treatment groups In spite of some alterations in electrocardiography, hematology, blood biochemistry, gross and microscopic findings, such effects were not considered to include toxicopathological significance, based on the marginal changes within normal ranges and lack of dose-dependency, consistent time-course and gender relationship Taken together, it is suggested that no observed adverse effect level (NOAEL) of Geranti Bio-Ge Yeast^[○!R] is considered to be 2,000 mg/kg in dogs, and that long-term treatment in clinical trials might not exert adverse effects
- 日本トキシコロジー学会の論文
- 2004-12-27
著者
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Kim Jong-choon
Coll. Of Veterinary Medicine Chonnam National Univ.
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KIM Yun-Bae
College of Veterinary Medicine, Chungbuk National University
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Lee Jong-soo
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Sunhee
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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Lee Jong-sung
Biotoxtech Co. Ltd.
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Lee Jong-sung
韓国
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Kang J‐k
Coll. Of Veterinary Medicine Chonnam National Univ.
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Kim Yun-bae
Dep. Of Medicine Univ. Of British Columbia Hospital
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Park Cheol-beom
Biotoxtech Co. Ltd.
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Kim Y
Department Of Public Health College Of Natural Sciences Keimyung University
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Kim Yun-bae
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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KANG Jong-Koo
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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Lee Hye-young
Biotoxtech Co Ltd Ochang Scientific And Industrial Complex
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Kim Sun-Hee
Biotoxtech Co., Ltd.
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PARK Jong-Il
Biotoxtech Co, Ltd, Ochang Scientific and Industrial Complex
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HWANG Zai-Zhi
Biotoxtech Co, Ltd, Ochang Scientific and Industrial Complex
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SOHN Tsang-Uk
GerantiPharm Co, Ltd
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Lee J
Kyung Hee Univ. Seoul Kor
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Park J‐i
Biotoxtech Co Ltd Ochang Scientific And Industrial Complex
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Kim Sun-hee
Biotoxtech Co. Ltd.
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Shin Sunhee
College Of Veterinary Medicine Chungbuk National University
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Sohn Tsang-uk
Gerantipharm Co Ltd
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Hwang Zai-zhi
Biotoxtech Co Ltd Ochang Scientific And Industrial Complex
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Lee J
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Cho Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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KIM Yun-Bae
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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Shin Sunhee
College of Veterinary Medicine and Research Institute of Veterinary Medicine
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- ORAL SINGLE- AND REPEATED-DOSE TOXICITY STUDIES ON GERANTI BIO-GE YEAST^[○!R], ORGANIC GERMANIUM FORTIFIED YEASTS, IN DOGS
- ORAL SINGLE- AND REPEATED-DOSE TOXICITY STUDIES ON GERANTI BIO-GE YEAST^[○!R], ORGANIC GERMANIUM FORTIFIED YEASTS, IN RATS
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