Acute and Repeated Inhalation Toxicity of 1-Bromopropane in SD Rats

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The acute and repeated inhalation toxicity of 1-bromopropane (1-BP) in SD rats were investigated. LC_<50> for four-hour exposure was 14,374 ppm (95% confidence limit: 13,624-15,596 ppm). It was revealed to be irritating to the eyes with lacrimation in all four-hour exposure rats. No other abnormal clinical signs and gross findings related to the 1-BP exposure were observed. An experiment on repeated exposure to 0, 50, 300, and 1,800 ppm for six hrs/day, five days/week, for eight weeks was conducted. A decrease in body weights and increase in relative liver weight in both male and female rats were observed in the 1,800 ppm exposure group (p<0.001 vs. control group). No other significant changes in feed consumption, urinanalysis, hematology and serum biochemistry were observed. Histopathological examinations did not reveal any 1-BP-related changes.
社団法人日本産業衛生学会の論文