Effect of Puerariae radix on c-Fos Expression in Hippocampus of Alcohol-Intoxicated Juvenile Rats(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Alcohol consumption is known to cause substantial neuronal loss in several regions of the brain. In Oriental medicine, medications based on Puerariae radix have been known to be of efficacy in the treatment of alcohol-related problems. In the present study, the effect of the aqueous extract of Puerariae radix on the expression of c-Fos, an immediate early gene whose expression is sometimes used as a marker for stimulus-induced changes in the metabolic activity of neurons, in the hippocampus of acutely alcohol-intoxicated juvenile rats was investigated via immunohistochemistry. In the first part of the experiment, Sprague-Dawley rats were divided into six groups: the control group, the alcohol-treated group, the alcohol- and 0.3 mg/kg Puerariae radix-treated group, the alcohol- and 3 mg/kg Puerariae radix-treated group, the alcohol- and 30 mg/kg Puerariae radix-treated group, and the alcohol- and 300 mg/kg Puerariae radix-treated group. In the second part of the experiment, animals were divided into four groups: the control group, the 30 mg/kg Puerariae radix-treated group, the alcohol-treated group, and the alcohol- and 30 mg/kg Puerariae radix-treated group. From the results, it was demonstrated that alcohol administration significantly decreases the number of Fos-positive cells in the various regions of the hippocampus, and Puerariae radix treatment inhibits the alcohol-induced suppression of the expression of Fos in the hippocampus in a dose-dependent manner. Puerariae radix exerted no significant effect on Fos expression in the hippocampus of normal rats. The results presented in this study suggest that Puerariae radix may alleviate alcohol-induced disruption of hippocampal functions.
- 社団法人日本薬学会の論文
- 2003-01-01
著者
-
Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim C‐j
Kyung Hee Univ. Seoul Kor
-
KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
-
LEE Taeck-Hyun
Department of Physiology, College of Medicine, Kyung Hee University
-
JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
-
SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
-
KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
-
KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
-
BAHN Geon-Ho
Department of Psychiatry, College of Medicine, Kyung Hee University
-
SHIN Hye-Sook
College of Nursing Science, Kyung Hee University
-
LIM Sabina
Department of Meridianology, College of Oriental Medicine, Kyung Hee University
-
Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim Ee-hwa
韓国
-
Shin H‐d
College Of Nursing Science Kyung Hee University
-
Lee T‐h
Department Of Physiology College Of Medicine Kyung Hee University
-
Lee Taeck-hyun
韓国
-
Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
-
Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
-
Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
-
Shin Hye-sook
College Of Nursing Science Kyung Hee University
-
Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
-
Lim Sabina
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
-
Lee Taeck-hyun
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
-
Bahn Geon-ho
Department Of Psychiatry College Of Medicine Kyung Hee University
-
Lim Sabina
Department of Applied Korean Medicine, College of Korean Medicine, Kyung Hee University
関連論文
- Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring
- Maternal Alcohol Administration Suppresses Expression of Nitric Oxide Synthase in the Hippocampus of Offspring Rats
- Effects of Corydalis Tuber on synthesis of NO and PGE_2 in murine macrophage RAW 264.7 cells stimulated by LPS(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Scie
- Atractylodes japonica Suppresses Lipopolysaccharide-Stimulated Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Macrophages (Pharmacology)
- Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells (Pharmacology)
- Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
- Folium mori Increases Cell Proliferation and Neuropeptide Y Expression in Dentate Gyrus of Streptozotocin-Induced Diabetic Rats
- Bee Venom Induces Apoptosis and Inhibits Expression of Cyclooxygenase-2 mRNA in Human Lung Cancer Cell Line NCI-H1299
- Effects of Paeonia radix on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in the Dorsal Raphe of Exercised Rats
- Effect of Puerariae radix on c-Fos Expression in Hippocampus of Alcohol-Intoxicated Juvenile Rats(Pharmacology)
- A dministration of Folium mori Extract Decreases Nitric Oxide Synthase Expression in the Hypothalamus of Streptozotocin-Induced Diabetic Rats
- Effects of Puerariae radix on Cell Proliferation and Nitric Oxide Synthase Expression in Dentate Gyrus of Alcohol-Intoxicated Sprague-Dawley Rats
- Serotonin Induces Apoptosis in PGT-β Pineal Gland Tumor Cells
- Effects of Corydalis Tuber on synthesis of NO and PGE_2 in murine macrophage RAW 264.7 cells stimulated by LPS(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Scie
- Nitric Oxide Induces Apoptosis in Mouse C2C12 Myoblast Cells
- Ginseng radix Increases Cell Proliferation in Dentate Gyrus of Rats with Streptozotocin-Induced Diabetes
- Protective Effects of Puerariae flos Against Ethanol-Induced Apoptosis on Human Neuroblastoma Cell Line SK-N-MC
- Harpagophytum procumbens Suppresses Lipopolysaccharide-Stimulated Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Fibroblast Cell Line L929
- Protective Effect of Gabapentin on N-Methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampal CA1 Neurons
- Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers
- Maternal swimming during pregnancy enhances short-term memory and neurogenesis in the hippocampus of rat pups
- Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats
- Daidzein Activates Choline Acetyltransferase from MC-IXC Cells and Improves Drug-Induced Amnesia
- Effects of Oleamide on Choline Acetyltransferase and Cognitive Activities(Food & Nutrition Science)
- Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
- Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
- Amygdalin Induces Apoptosis through Regulation of Bax and Bcl-2 Expressions in Human DU145 and LNCaP Prostate Cancer Cells(Pharmacology)
- Modulation of Corydalis tuber on Glycine-Induced Ion Current in Acutely Dissociated Rat Periaqueductal Gray Neurons(Pharmacology)
- Antinociceptive Effect of Amygdalin Isolated from Prunus armeniaca on Formalin-Induced Pain in Rats(Pharmacognosy)
- Armeniacae semen Extract Suppresses Lipopolysaccharide-Induced Expressions of Cycloosygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells(Pharmacology)
- Effect of Ginseng radix on c-Fos Expression in the Hippocampus of Streptozotocin-Induced Diabetic Rats
- Activation Effects of Allium Tuberosum Rottl. on Choline Acetyltransferase
- Ginseng radix Increases Cell Proliferation in Dentate Gyrus of Rats with Streptozotocin-Induced Diabetes
- Related Factors with Sa-Sang Constitution(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Science)
- Protective Effects of Kaempferol (3,4′,5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
- Activation Effects of Allium Tuberosum Rottl. on Choline Acetyltransferase
- Protective Effects of Kaempferol (3,4',5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
- Effects of Phellinus linteus Administration on Serotonin Synthesis in the Brain and Expression of Monocarboxylate Transporters in the Muscle during Exhaustive Exercise in Rats
- Effects of Methoxsalen from Poncirus trifoliata on Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment
- Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal-separated rat pups
- Neuroprotective Effect of trans-Cinnamaldehyde on the 6-Hydroxydopamine-Induced Dopaminergic Injury