Neuroprotective Effect of trans-Cinnamaldehyde on the 6-Hydroxydopamine-Induced Dopaminergic Injury

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概要

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• The anti-inflammatory and neuroprotective effects of trans-cinnamaldehyde (TCA) were investigated on the inflammatory cells and the dopaminergic degeneration in mice. TCA inhibited the up-regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-induced inflammatory BV2 microglial cells. To investigate the TCA efficacy on the 6-hydroxydopamine (6-OHDA)-induced dopaminergic degeneration in mice, an intracerebroventricular injection of 6-OHDA was given to the mice, and TCA (30 mg/kg) was intraperitoneally administered. At 7 d after the 6-OHDA injection, 6-OHDA led to a severe loss of tyrosine hydroxylase (TH)-positive dopaminergic neurons in the striatum and substantia nigra (SN). On the other hand, TCA dramatically maintained the number of TH-positive dopaminergic neurons in the striatum and SN regions of the 6-OHDA-treated mice, which indicates that TCA is able to inhibit the 6-OHDA-induced reduction of TH expression in the dopaminergic neurons in the striatum and SN regions. TCA also inhibited the induction of iNOS and COX-2 in the 6-OHDA model, similarly as shown in the LPS-induced inflammatory BV2 microglial cells. These results indicate that TCA has a neuroprotective effect on dopaminergic neurons and that this effect may be associated with the inhibition of inflammatory responses. These findings suggest that TCA may be a therapeutic candidate for the prevention of inflammation-mediated neurodegenerative diseases.

• 公益社団法人 日本薬学会の論文

著者

• LIM Sabina

  Department of Meridianology, College of Oriental Medicine, Kyung Hee University

• CHOI Yeong-Gon

  Department of Dermatology, Seoul National University College of Medicine

• Kim Sung-hoon

  Cancer Preventive Material Development Research Center College Of Oriental Medicine Kyunghee Univers

• Lee Je-Hyun

  Department of Herbology, College of Oriental Medicine, Dongguk University

• Kim Sung-Hoon

  Cancer Preventive Material Development Research Center, College of Korean Medicine, Kyung Hee University

• Pyo Ji-Hi

  Department of Applied Korean Medicine, College of Korean Medicine, Kyung Hee University

• Jeong You-Kyung

  Department of Applied Korean Medicine, College of Korean Medicine, Kyung Hee University

• Yeo Sujung

  Department of Applied Korean Medicine, College of Korean Medicine, Kyung Hee University

• Jeong Mi-Young

  Department of Applied Korean Medicine, College of Korean Medicine, Kyung Hee University

• Choi Yeong-Gon

  Department of Applied Korean Medicine, College of Korean Medicine, Kyung Hee University

• Lim Sabina

  Department of Applied Korean Medicine, College of Korean Medicine, Kyung Hee University

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• Neuroprotective Effect of trans-Cinnamaldehyde on the 6-Hydroxydopamine-Induced Dopaminergic Injury

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