Ethyl Acetate Soluble Fraction of Cnidium officinale MAKINO Inhibits Neuronal Cell Death by Reduction of Excessive Nitric Oxide Production in Lipopolysaccharide-Treated Rat Hippocampal Slice Cultures and Microglia Cells
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概要
- 論文の詳細を見る
In the present work, we found that the ethyl acetate-soluble fraction of Cnidium officinale <sc>MAKINO</sc> (COEA) decreased nitric oxide (NO) production in the lipopolysaccharide (LPS)-stimulated BV-2 and primary microglia and suppressed expression of inducible nitric oxide synthase (iNOS) in BV-2 cells with the same pattern of NO production. In addition, we showed that excessive NO production played an important role in neuronal cell death in LPS-treated rat hippocampal slice cultures. Our data suggest that the COEA inhibits neuronal cell death by reduction of excessive NO production in LPS-treated rat hippocampal slice cultures. The ethyl acetate-soluble fraction of C. officinale reduced propidium iodide uptake and NO production in cultured media at the same time.
- 社団法人 日本薬理学会の論文
- 2003-05-01
著者
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LEE Kang
Department of Machine Intelligence and Systems Engineering, Tohoku University
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Kim Sun
Department Of Chemical Engineering Sogang University
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Kim Sun
Graduate School Of East-west Medicine Kyung Hee Univ.
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Kim Sung-soo
Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University
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Kim Sung-soo
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Kim H
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Kim S
Graduate School Of East-west Medicine Kyung Hee Univ.
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KIM Jeong
Department of Information Electronics Engineering, Ewha Womans University
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LEE Pyeongjae
Department of Natural Medicine Resources, Semyung University
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LEE Kunho
Graduate School of East-West Medical Science, Kyung Hee University
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Lee Kun
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Sun
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Jeong
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Lee Kang
Department Of Sericulture And Entomology National Institute Of Agriculture Science And Technology
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KIM Hocheol
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyunghee University
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SON Dongwook
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee Universit
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Kim Jeongmin
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Jeong
Department Of Anatomy Wonkwang University School Of Medicine
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Kim Hong
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Lee Kang
Department Of Electronics Engineering Konkuk University
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Kim S
Graduate School Of East-west Medical Science Kyung Hee University
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Son Dongwook
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Lee Pyeongjae
Department Of Natural Medicine Resources Semyung University
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Lee Pyeongjae
Department Of Sericulture And Entomology National Institute Of Agricultural Science & Technology
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Kim Sun
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Kim H
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Hocheol
Department Of Herbal Pharmacology College Of Oriental Medicine Kyung Hee University:korea Institute
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Son Dongwook
Kt&g Central Res. Inst.
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Lee Kang
Department Of Chemistry Research Institute Of Natural Science And Environmental Biotechnology Nation
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Kim Sun
East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.
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Kim Sun
Department Of Animal Science And Technology Seoul National University
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Lee Kang
Department of Bioengineering and Robotics, Tohoku University, 6-6-01 Aza Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
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Lee Pyeongjae
Department of Agricultural Biology, National Institute of Agricultural Science & Technology
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