Curcumin Suppresses Lipopolysaccharide-Induced Cyclooxygenase-2 Expression by Inhibiting Activator Protein 1 and Nuclear Factor кB Bindings in BV2 Microglial Cells

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概要

• 論文の詳細を見る

• Inflammation is a significant component of chronic neurodegenerative diseases. Cyclooxygenase-2 (COX-2) is expressed in activated microglial cells and appears to be an important source of prostaglandins during inflammatory conditions. To investigate the effect of curcumin on COX-2 gene expression in microglial cells, we treated lipopolysaccharide (LPS)-challenged BV2 microglial cells with various concentrations of curcumin. Curcumin significantly inhibited LPS-mediated induction of COX-2 expression in both mRNA and protein levels in a concentration-dependent manner. COX-2 enzyme activity was also inhibited in accordance with mRNA and protein levels. Furthermore, curcumin markedly inhibited LPS-induced nuclear factor κB (NF-κB) and activator protein 1 (AP-1) DNA bindings. These data suggest that curcumin suppresses LPS-induced COX-2 gene expression by inhibiting NF-κB and AP-1 DNA bindings in BV2 microglial cells.

• 社団法人 日本薬理学会の論文
• 2004-03-01

著者

• KIM Sung-Soo

  Department of Internal Medicine, Chonnam National University Hospital

• YIM Sung-Vin

  Department of Pharmacology, College of Medicine, Kangwon National University

• Kim Sung-soo

  Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno

• Kim Sung-soo

  Department Of Pharmacology College Of Medicine Kangwon National University

• KANG Gu

  Department of Pathology, College of Medicine, Kangwon National University

• KONG Pil-Jae

  Department of Pharmacology, College of Medicine, Kangwon National University

• YUH Young-Jin

  Department of Pharmacology, College of Medicine, Kangwon National University

• LIM So-Young

  Department of Anesthesiology, College of Medicine, Hallym University

• CHUN Wanjoo

  Department of Pharmacology, College of Medicine, Kangwon National University

• Kang Gu

  Department Of Pathology College Of Medicine Kangwon National University

• Kong Pil-jae

  Department Of Pharmacology College Of Medicine Kangwon National University

• Yuh Young-jin

  Department Of Pharmacology College Of Medicine Kangwon National University

• Chun Wanjoo

  Department Of Pharmacology College Of Medicine Kangwon National University

• Lim So-young

  Department Of Anesthesiology College Of Medicine Hallym University

• Yim Sung-vin

  Department Of Pharmacology College Of Medicine Kyung Hee University

• Yim Sung-vin

  Department Of Pharmacology College Of Medicine Kohwang Medical Research Institute Kyung Hee Universi

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