Regulation of Melanin Synthesis by Selenium-Containing Carbohydrates
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概要
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This study reports depigmenting potency of selenium-containing carbohydrates, which would be based upon the finding of direct inhibition to mushroom tyrosinase. Two selenoglycosiede, SG-3 (bis (2, 3, 4-tri-O-acetyl-β-D-arabinopyranosyl) selenide) and SG-8 (4'-methylbenzoyl 2, 3, 4, 6-tetra-O-acetyl-D-selenomanopyranoside) among eleven selenium-containing compounds examined, were discovered to be effective depigmenting compounds on a mushroom tyrosinase inhibitory assay. SG-3 exhibited a competitive inhibition effect that was similar to kojic acid, well-known tyrosinase inhibitor. At 100μM and 150μM, SG-8 had an uncompetitive inhibitory effect that was higher than kojic acid. A study of a melan-a cell originated-tyrosinase inhibition assay showed that SG-8 had a lower inhibitory effect than kojic acid. SG-3 showed a similar inhibition effect to kojic acid on the melan-a cell-originated tyrosinase inhibitory assay. SG-8 showed dose-dependently cytotoxicity in a study of inhibition melanin synthesis by melan-a cells. Most melan-a cells did not survive after being treated with 20μM of SG-8. At 10μM, SG-3 inhibited melanin synthesis in the melan-a cells, and the effect was similar to phenylthiourea, which is a well-known inhibitor of melanin synthesis. Therefore, SG-3 is a new candidate for depigmenting reagents.
- 2006-03-01
著者
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KIM Sun
Graduate School of East-West Medicine, Kyung Hee University
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Koike Minako
岐阜県国際バイオ研究所
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Kim Sun
Graduate School Of East-west Medicine Kyung Hee Univ.
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Kim Sung-soo
Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University
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Kim Sung-soo
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Kim S
Graduate School Of East-west Medicine Kyung Hee Univ.
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AHN Sang
Graduate School of East-West Medical Science, Kyung Hee University
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KOKETSU Mamoru
Division of Instrumental Analysis, Life Science Research Center, Gifu University
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ISHIHARA Hideharu
Department of Chemistry, Faculty of Engineering, Gifu University
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LEE Soo
Graduate School of East-West Medical Science, Kyung Hee University
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HA Sang
Graduate School of East-West Medical Science, Kyung Hee University
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LEE Kun
Graduate School of East-West Medical Science, Kyung Hee University
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KANG Tong
Graduate School of East-West Medical Science, Kyung Hee University
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LEE Kunho
Graduate School of East-West Medical Science, Kyung Hee University
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Lee Kun
Graduate School Of East-west Medical Science Kyung Hee University
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Ha Sang
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Sun
Graduate School Of East-west Medical Science Kyung Hee University
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Ahn Sang
Graduate School Of East-west Medical Science Kyung Hee University
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Kang Tong
Dep. Of Oriental Pharmaceutical Dev. Nambu Univ.
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Kang Tong
Graduate School Of East-west Medical Science Kyunghee University
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Lee Kang
Department Of Sericulture And Entomology National Institute Of Agriculture Science And Technology
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Lee Soo
Graduate School Of East-west Medical Science Kyung Hee University
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Kim S
Graduate School Of East-west Medical Science Kyung Hee University
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Koketsu Mamoru
Division Of Instrumental Analysis Life Science Research Center Gifu University
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Ishihara H
Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive
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Koketsu Mamoru
Research Center Suntory Limited
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Kim Sun
Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky
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Kim Sun
East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.
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Ishihara Hideharu
Department Of Chemistry Faculty Of Engineering Gifu University
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Ishihara Hideharu
Dep. Of Chemistry Fac. Of Engineering Gifu Univ.
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Mamoru Koketsu
Research Center Suntory Limited
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Kim Sun
Graduate School Of East-west Medical Science
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