Inhibition of Tyrosinase Activity by N, N-Unsubstituted Selenourea Derivatives(Medicinal Chemistry)
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概要
- 論文の詳細を見る
This study investigated inhibitory effects of N, N-unsubstituted selenourea derivatives on tyrosinase activity. Three types of N, N-unsubstituted selenoureas derivatives exhibited inhibitory effect on dopa (3,4-dihydroxy-phenylalanine) oxidase activity of mushroom tyrosinase. Compound D at a concentration of 200μM exhibited 55.5% of inhibition on dopa oxidase activity of mushroom tyrosinase. This inhibitory effect was higher than that of kojic acid (39.4%), a well known tyrosinase inhibitor. Moreover, the compound D identified as a noncompetitive inhibitor by Lineweaver-Burk plot analysis. In addition, compound D also inhibited the melanin production in melan-a cells.
- 社団法人日本薬学会の論文
- 2005-05-01
著者
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KIM Sun
Graduate School of East-West Medicine, Kyung Hee University
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Koike Minako
岐阜県国際バイオ研究所
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Kim Sun
Graduate School Of East-west Medicine Kyung Hee Univ.
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Choi Sang
Korea Res. Inst. Of Chemical Technol. Daejeon Kor
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Choi Sang
韓国
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Kim Sung-soo
Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University
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Kim Sung-soo
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Kim S
Graduate School Of East-west Medicine Kyung Hee Univ.
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KOKETSU Mamoru
Division of Instrumental Analysis, Life Science Research Center, Gifu University
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ISHIHARA Hideharu
Department of Chemistry, Faculty of Engineering, Gifu University
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HA Sang
Graduate School of East-West Medical Science, Kyung Hee University
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LEE Kunho
Graduate School of East-West Medical Science, Kyung Hee University
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PARK Ji
Graduate School of East-West Medical Science, Kyung Hee University
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Lee Kun
Graduate School Of East-west Medical Science Kyung Hee University
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Ha Sang
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Sun
Graduate School Of East-west Medical Science Kyung Hee University
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Park Ji
Graduate School Of East-west Medical Science Kyung Hee University
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Lee Kang
Department Of Sericulture And Entomology National Institute Of Agriculture Science And Technology
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Kim S
Graduate School Of East-west Medical Science Kyung Hee University
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Koketsu Mamoru
Division Of Instrumental Analysis Life Science Research Center Gifu University
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Choi S
Kyung Hee Univ. Seoul Kor
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Ishihara H
Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive
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Choi Sang
Korea Food Res. Inst.
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Koketsu Mamoru
Research Center Suntory Limited
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Park Ji-ho
Dept. Of Electronics & Information Eng. Toyohashi Univ. Of Tech.
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Kim Sun
Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky
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Kim Sun
East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.
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Park Ji-ho
Graduated School Of East-west Medical Sci. Kyung Hee Univ.
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Ishihara Hideharu
Department Of Chemistry Faculty Of Engineering Gifu University
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Ishihara Hideharu
Dep. Of Chemistry Fac. Of Engineering Gifu Univ.
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Mamoru Koketsu
Research Center Suntory Limited
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Kim Sun
Graduate School Of East-west Medical Science
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