Inhibition of Tyrosinase Activity by N, N-Unsubstituted Selenourea Derivatives(Medicinal Chemistry)

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概要

• 論文の詳細を見る

• This study investigated inhibitory effects of N, N-unsubstituted selenourea derivatives on tyrosinase activity. Three types of N, N-unsubstituted selenoureas derivatives exhibited inhibitory effect on dopa (3,4-dihydroxy-phenylalanine) oxidase activity of mushroom tyrosinase. Compound D at a concentration of 200μM exhibited 55.5% of inhibition on dopa oxidase activity of mushroom tyrosinase. This inhibitory effect was higher than that of kojic acid (39.4%), a well known tyrosinase inhibitor. Moreover, the compound D identified as a noncompetitive inhibitor by Lineweaver-Burk plot analysis. In addition, compound D also inhibited the melanin production in melan-a cells.

• 社団法人日本薬学会の論文
• 2005-05-01

著者

• KIM Sun

  Graduate School of East-West Medicine, Kyung Hee University

• Koike Minako

  岐阜県国際バイオ研究所

• Kim Sun

  Graduate School Of East-west Medicine Kyung Hee Univ.

• Choi Sang

  Korea Res. Inst. Of Chemical Technol. Daejeon Kor

• Choi Sang

  韓国

• Kim Sung-soo

  Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University

• Kim Sung-soo

  Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno

• Kim S

  Graduate School Of East-west Medicine Kyung Hee Univ.

• KOKETSU Mamoru

  Division of Instrumental Analysis, Life Science Research Center, Gifu University

• ISHIHARA Hideharu

  Department of Chemistry, Faculty of Engineering, Gifu University

• HA Sang

  Graduate School of East-West Medical Science, Kyung Hee University

• LEE Kunho

  Graduate School of East-West Medical Science, Kyung Hee University

• PARK Ji

  Graduate School of East-West Medical Science, Kyung Hee University

• Lee Kun

  Graduate School Of East-west Medical Science Kyung Hee University

• Ha Sang

  Graduate School Of East-west Medical Science Kyung Hee University

• Kim Sun

  Graduate School Of East-west Medical Science Kyung Hee University

• Park Ji

  Graduate School Of East-west Medical Science Kyung Hee University

• Lee Kang

  Department Of Sericulture And Entomology National Institute Of Agriculture Science And Technology

• Kim S

  Graduate School Of East-west Medical Science Kyung Hee University

• Koketsu Mamoru

  Division Of Instrumental Analysis Life Science Research Center Gifu University

• Choi S

  Kyung Hee Univ. Seoul Kor

• Ishihara H

  Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive

• Choi Sang

  Korea Food Res. Inst.

• Koketsu Mamoru

  Research Center Suntory Limited

• Park Ji-ho

  Dept. Of Electronics & Information Eng. Toyohashi Univ. Of Tech.

• Kim Sun

  Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky

• Kim Sun

  East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.

• Park Ji-ho

  Graduated School Of East-west Medical Sci. Kyung Hee Univ.

• Ishihara Hideharu

  Department Of Chemistry Faculty Of Engineering Gifu University

• Ishihara Hideharu

  Dep. Of Chemistry Fac. Of Engineering Gifu Univ.

• Mamoru Koketsu

  Research Center Suntory Limited

• Kim Sun

  Graduate School Of East-west Medical Science

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