Anxiolytic-Like Effects of Gastrodia elata and Its Phenolic Constituents in Mice(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• The purpose of this study was to characterize the putative anxiolytic-like effects of the aqueous extract of the rhizome of Gastrodia elata along with its phenolic constituents, 4-hydroxybenzyl alcohol (HA) and 4-hyroxy-benzaldehyde (HD), using an elevated plus maze (EPM) in mice. The mice were administered either the aqueous G. elata extract orally or received an intraperitoneal injection of the phenolic constituents, 1 h before the behavioral evaluation in the EPM. A single treatment of the aqueous G. elata extract significantly increased the percentage of time spent and arm entries into the open arms of the EPM versus the saline controls. Among the phenolic constituents of G. elata, HA and HD significantly increased the percentage of time spent and arm entries into the open arms of the EPM versus saline controls (p<0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with the saline controls. In addition, the anxiolytic-like effects of G. elata extract were blocked by both WAY 100635 (0.3mg/kg, i.p.), a 5-HT_<1A> receptor antagonist, and flumazenil (10mg/kg, i.p.), a GABA_A receptor antagonist. The anxiolytic-like effects of HA were inhibited by WAY 100635 and the effects of HD were antagonized by flumazenil. These results indicate that G. elata is an effective anxiolytic agent, and suggests that the anxiolytic-like effects of G. elata via the serotonergic nervous system depends on HA and those effects of G. elata via the GABAergic nervous system depends on HD.

• 社団法人日本薬学会の論文
• 2006-02-01

著者

• Kim Sun

  Department Of Chemical Engineering Sogang University

• Ryu Jong

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• JUNG Ji

  Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit

• YOON Byung

  Department of Life and Nanopharmaceutical Sciense, Kyung Hee University

• Kim Sung-soo

  Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University

• Ryu Jong

  Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He

• Kim Sun

  Graduate School Of East-west Medical Science Kyung Hee University

• Jung Ji

  Department Of Herbal Medicinal Resource College Of Health And Welfare Daegu Haany University

• Ryu Jong

  Department Of Oriental Pharmaceutical Science Kyunghee University

• Yoon Byung

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• OH Hye

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

• AHN Jae-Hyeong

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

• PARK Sang-Yong

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

• Jung Ji

  Department Of Genetic Epidemiology Snp Genetics Inc.

• Ahn Jae-hyeong

  Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University

• Yoon Byung

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University

• Park Sang-yong

  Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University

• Park Sang-yong

  Department Of Dermatology College Of Medicine Korea University

• Kim Sun

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

• Oh Hye

  Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University

• Kim Sun

  East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.

• Kim Sun

  Department Of Animal Science And Technology Seoul National University

• JUNG Ji

  Department of Anatomy, College of Medicine, Hallym University

• Park Sang-Yong

  Department of Biochemistry, College of Pharmacy, Kyung-Hee University

関連論文

• Ameliorating effect of a herbal medicinal prescription, Kyung-Ok-Ko, on scopolamine-induced memory impairment in mice
• Taraxinic Acid, a Hydrolysate of Sesquiterpene Lactone Glycoside from the Taraxacum coreanum NAKAI, Induces the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells
• IS-85 The relationship between serum follicle-stimulating hormone and estradiol levels and urodynamic results in patients with pelvic floor dysfunction(Group11 Women's Health2,International Session)
• Effects of Paeonia radix on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in the Dorsal Raphe of Exercised Rats
• Multiple myeloma in Korea : past, present, and future perspectives. Experience of the Korean Multiple Myeloma Working Party
• Regulation of Melanin Synthesis by Selenium-Containing Carbohydrates
• Potent Inhibitory Effects of N-Aryl S-Alkylthiocarbamate Derivatives on the Dopa Oxidase Activity of Mushroom Tyrosinase
• Inhibitory Effects of Saururus chinensis (LOUR.) BAILL on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice(Pharmacology)
• 2. Selection of Therapeutic Modalities for Paraclinoid Internal Carotid Artery Aneurysms : Angiographic Results and Long-term Outcome in 236 Consecutive Cases(Internet Lecture "Connecting the World",Special Program,The 29th Annual Meeting of The Japanese
• No Association of Pro12Ala Polymorphism of PPAR-γ Gene With Coronary Artery Disease in Korean Subjects
• Relationship Between Serum Uric Acid Concentration and Insulin Resistance and Metabolic Syndrome
• Sex Difference in the Relationship Between Insulin Resistance and Corrected QT Interval in Non-Diabetic Subjects
• P-48 Regulation of contact hypersensitivity in BALB/c mice repeatedly elicited with picryl-chloride.(Proceedings of the 27th Annual Meeting)
• Inhibition of Methanol Extract from the Fruits of Kochia scoparia on Lipopolysaccharide-Induced Nitric Oxide, Prostagladin E_2, and Tumor Necrosis Factor-α Production from Murine Macrophage RAW 264.7 Cells (Pharmacognosy)
• Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F_1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus(Pharmacognosy)
• Inhibition of Methanol Extract from the Aerial Parts of Saururus chinensis on Lipopolysaccharide-Induced Nitric Oxide and Prostagladin E_2 Production from Murine Macrophage RAW 264.7 Cells
• Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols
• In Vitro Antiinflammatory Activity of Kalopanaxsaponin A Isolated from Kalopanax pictus in Murine Macrophage RAW 264.7 Cells
• Induction of Apoptosis by Yomogin in Human Promyelocytic Leukemic HL-60 Cells(Pharmacognosy)
• Clinical efficacy of the gonadotropin-releasing hormone antagonist, ganirelix, in Korean women undergoing controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer with recombinant follicle-stimulating hormone
• Protective Effect of (4-Methoxybenzylidene)-(3-methoxynophenyl)amine against Neuronal Cell Death Induced by Oxygen and Glucose Deprivation in Rat Organotypic Hippocampal Slice Culture(Medicinal Chemistry)
• Inhibition of Tyrosinase Activity by N, N-Unsubstituted Selenourea Derivatives(Medicinal Chemistry)
• 1,3-Selenazol-4-one Derivatives Inhibit Inducible Nitric Oxide-Mediated Nitric Oxide Production in Lipopolysaccharide-Induced BV-2 Cells (Pharmacology)
• Inhibitory Effects of 1,3-Selenazol-4-one Derivatives on Mushroom Tyrosinase
• The Seed Extract of Cassia obtusifolia Offers Neuroprotection to Mouse Hippocampal Cultures
• Spinal cholinergic mechanism of the relieving effects of electroacupuncture on cold and warm allodynia in a rat model of neuropathic pain
• Electroacupuncture Potentiates the Antiallodynic Effect of Intrathecal Neostigmine in a Rat Model of Neuropathic Pain
• P1-IS-25 BAG-1 expression in normal endometrium, endometrial hyperplasia and endometrial cancer. : Is it prognostic marker?
• High-Dosage Pyridoxine-Induced Auditory Neuropathy and Protection with Coffee in Mice(Pharmacology)
• The Analgesic Effects of Automatically Controlled Rotating Acupuncture in Rats : Mediation by Endogenous Opioid System
• Performance of DS-CDM-SQAM in Nonlinear Land Mobile Satellite Broadcasting Environments(Components)
• The Seed Extract of Cassia obtusifolia Ameliorates Learning and Memory Impairments Induced by Scopolamine or Transient Cerebral Hypoperfusion in Mice
• Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats(Pharmacology)
• Enhancement of Neuroprotection of Mulberry Leaves (Morus alba L.) Prepared by the Anaerobic Treatment against Ischemic Damage(Pharmacology)
• Anxiolytic-Like Effects of Gastrodia elata and Its Phenolic Constituents in Mice(Pharmacology)
• Zeaxanthin Dipalmitate from Lycium chinense Fruit Reduces Experimentally Induced Hepatic Fibrosis in Rats
• A Novel Cerebroside from Lycii Fructus Preserves the Hepatic Glutathione Redox System in Primary Cultures of Rat Hepatocytes
• ラット神経幹細胞の分化におけるギャップジャンクション細胞間コミュニケーション (GJIC) の役割 : p38 および ERK1/2 経路の関与(毒性学)
• Synthesis and Characterization of Resorcinol-Formaldehyde Organic Aerogel
• Mulberroside F Isolated from the Leaves of Morus alba Inhibits Melanin Biosynthesis
• Interference Cancellation and Multipath Mitigation Algorithm for GPS Using Subspace Projection Algorithms
• Gluco-obtusifolin and Its Aglycon, Obtusifolin, Attenuate Scopolamine-Induced Memory Impairment
• P1-IS-100 Correlation between estrogen and serum adipocytokine in premenopause and postmenopause women
• Significance of CD44v6 expression in gynecologic malignancies
• Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
• 腎細胞癌の進展におけるVEGFの意義
• Ethyl Acetate Soluble Fraction of Cnidium officinale MAKINO Inhibits Neuronal Cell Death by Reduction of Excessive Nitric Oxide Production in Lipopolysaccharide-Treated Rat Hippocampal Slice Cultures and Microglia Cells
• (4-Methoxy-benzylidene)-(3-methoxy-phenyl)-amine, a Nitrogen Analog of Stilbene as a Potent Inhibitor of Melanin Production
• Ginsenoside Rh2 Ameliorates Scopolamine-Induced Learning Deficit in Mice
• SELECTIVE EFFECT OF CHRONIC LEAD INGESTION ON TYROSINE HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
• Expression of transforming acidic coiled-coil containing protein 3 is a novel independent prognostic marker in non-small cell lung cancer
• Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women
• A New Caffeoly Quinic Acid from Aster scaber and Its Inhibitory Activity against Human Immunodeficiency Virus-1 (HIV-1) Integrase
• Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
• 犬の実験的慢性関節炎に対する刺針療法の有効性のサーモグラフィーによる評価(外科学)
• Reliability of Thin Gate Oxides Irradiated under X-Ray Lithography Conditions
• Gate Oxide Reliability Concern Associated with X-Ray Lithography
• Induction of Nerve Growth Factor by Butanol Fraction of Liriope platyphylla in C6 and Primary Astrocyte Cells(Pharmacognosy)
• Uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase
• Mangiferin Ameliorates Scopolamine-Induced Learning Deficits in Mice(Pharmacology)
• Syntheses and Characterization of the Alternating Polymers Based on Cyclopenta[def]phenanthrene Backbone with Spiro Group
• Synthesis and Characterization of Novel Conjugated Polymer with 4H-Cyclopenta[def]phenanthrene and the Sulfanyl Group
• IS-87 The relationship between the intensity of intra-amniotic inflammation and the presence and severity of histologic chorioamnionitis in preterm births(Group11 Perinatology3,International Session)
• アルミナにより表面処理した天然黒鉛の電気化学特性の改善
• Synthesis of MnMoO_4 as High Capacity Anode Material for Li Secondary Battery
• Neuroprotective and Neurotrophic Effects of Quinic Acids from Aster scaber in PC12 Cells
• Effect of Dietary Level of Pectin on Immunoglobulin and Cytokine Production by Mesenteric Lymph Node Lymphocytes and Interleukin-2 Receptor in Rats
• Decreased RR Interval Complexity and Loss of Circadian Rhythm in Patients With Congestive Heart Failure
• Efficacy of Dietary Aloe vera Supplementation on Hepatic Cholesterol and Oxidative Status in Aged Rats
• P1-IS-104 Comparison of Major Complication Rates among LAVH, LH, TLH
• P1-IS-101 Effects of HT and Livial on Uterine Myoma in Postmenopausal Women
• P1-IS-57 Arterial embolization for bleeding after hystrectomy for intractable postpartum hemorrhage : A Case Report
• Proteomic Analysis in Cyclosporin A-Induced Overgrowth of Human Gingival Fibroblasts
• An Efficient Speech Enhancement Algorithm for Digital Hearing Aids Based on Modified Spectral Subtraction and Companding(Speech and Hearing)
• B17 A study on interaction enhancement among learners at on-line education : Focused on utilization of Blog
• B17 A study on interaction enhancement among learners at on-line education : Focused on utilization of Blog
• Study of Transport and Dielectric of Resistive Memory States in NiO Thin Film
• Cerebral vasculitis in Henoch-Schonlein purpura : MRI and MRA findings, treated with plasmapheresis alone
• Lack of microsatellite instability in neoplasms of ampulla of Vater
• Rational Type of Laparoscopic Hysterectomy and Safety in Anesthetic Profiles
• Two Uterine Arterial Management Methods in Laparoscopic Hysterectomy
• Analysis of Tissue-Specific Expression of Human Type II Collagen cDNA Driven by Different Sizes of the Upstream Region of the β-Casein Promoter
• Oil Revovery from Scrap Tires by Low-Temperature Supercritical Decomposition with Toluene and Cyclohexane
• High Dosage Sildenafil Induces Hearing Impairment in Mice(Miscellaneous)
• A New Approach for Personal Identification Based on dVCG
• A Survey about the Volunteers in Dental Disabled Voluntary Organization
• Performance Evaluation of IEEE 802.11 Distributed Coordination Function with Virtual Group(Terrestrial Radio Communications)
• IS-101 WRN gene expression in vaginal walls of women with pelvic organ prolapse(Group11 Women's Health1,International Session)
• Changes in Muscle Fiber Size and in the Composition of Myosin Heavy Chain Isoforms of Rabbit Extraocular Rectus Muscle Following Recession Surgery
• Power and Rate Adaptations in Multicarrier DS/CDMA Communications over Rayleigh Fading Channels(Wireless Communication Technologies)
• Adaptive DS/CDMA Packet Radio Communications over Indoor Multipath Fading Channels(Wireless Communication Technologies)
• Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma
• Diagnostic Accuracy of Ultrasound Features in Thyroid Microcarcinomas
• Antioxidative Activity of Sulfur-containing Flavor Compounds in Garlic
• Effects of Corydaline from Corydalis Tuber on Gastric Motor Function in an Animal Model
• Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis
• Binding Characteristics of a Histamine H3-Receptor Antagonist, [3H]S-Methylthioperamide: Comparison with [3H](R)α-Methylhistamine Binding to Rat Tissues
• Hippocampus-dependent spatial learning and memory are impaired in growth hormone-deficient spontaneous dwarf rats
• Angelica keiskei ameliorates scopolamine-induced memory impairments in mice
• Involvement of histaminergic system in the anxiolytic-like activities of Morus alba L. leaves in mice

もっと見る 閉じる

スポンサーリンク