Ameliorating effect of a herbal medicinal prescription, Kyung-Ok-Ko, on scopolamine-induced memory impairment in mice
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概要
- 論文の詳細を見る
韓国の伝統医薬処方中強壮剤として広く使用されている瓊玉膏は高麗人参,地黄,茯苓,蜂蜜,枸杞子,沈香など数種の生薬で構成されている。本研究では,マウスでスコポラミンによって誘発される学習と記憶の障害に対する瓊玉膏の効果が評価された。瓊玉膏の改善効果は受動回避試験,Y迷路試験および水迷路試験によって調べられた。薬剤誘発性健忘はスコポラミン(1mg/kg)の腹腔内投与によって誘導された。受動回避実験及びY-迷路実験においてスコポラミンで誘起された認知障害は瓊玉膏の経口投与(1および2g/kg)によって有意義に回復された(p<0.05)。モリス水迷路試験では1g/kgの用量で脱出時間を短くした。瓊玉膏は試験管内試験では用量依存的なアセチルコリンエステラーゼ阻害活性をも見せた(IC_<50>value;162μg/ml)。アセチルコリンエステラーゼ阻害活性はex-vivo試験でも観察された。これらの結果は瓊玉膏が認知障害治療に役に立つかもしれないこととその有益な効果はコリン作動性神経伝達を強化する系を部分的に経由していることを示唆している。
- 2009-02-28
著者
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KIM Dong
Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
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KIM Sun
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University Scho
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Kim Sun
Department Of Chemical Engineering Sogang University
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Kim Sun
Department Of Life And Nanopharmaceutical Science Kyung Hee University
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Kim Sun
Department Of Life And Nanopharmaceutical Sciense Kyung Hee University
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SHIN Bum
Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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LEE Yong
R&D Center, Kwang Dong Pharmaceutical Co., Ltd.
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KIM Dong-hee
R&D Center, Kwang Dong Pharmaceutical Co., Ltd.
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PARK Chan
R&D Center, Kwang Dong Pharmaceutical Co., Ltd.
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CHO Hi-Jae
R&D Center, Kwang Dong Pharmaceutical Co., Ltd.
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YAMAMOTO Yutaka
Tochimoto Tenkaido Co., Ltd.
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KANG Dong
Tochimoto Tenkaido Co., Ltd.
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LEE Seungjoo
Department of Life and Nanopharmaceutical Sciense, Kyung Hee University
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YOON Byung
Department of Life and Nanopharmaceutical Sciense, Kyung Hee University
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柳 鍾薫
慶煕大学校薬学大學韓薬学科
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Ryu Jong
Department Of Oriental Pharmaceutical Science College Of Pharmacy
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Shin Bum
Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University
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Cho Hi-jae
R&d Center Kwang Dong Pharmaceutical Co. Ltd.
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Kim Dong-hee
R&d Center Kwang Dong Pharmaceutical Co. Ltd.
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Lee Seungjoo
Department Of Life And Nanopharmaceutical Sciense Kyung Hee University
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Lee Yong
R&d Center Kwang Dong Pharmaceutical Co. Ltd.
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Yamamoto Yutaka
Tochimoto Tenkaido Co. Ltd.
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Yoon Byung
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Kim Dong
Department Of Anatomy School Of Medicine Kyungpook National University
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Kim Sun
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Yoon Byung
Department Of Life And Nanopharmaceutical Sciense Kyung Hee University
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Kim Sun
Department Of Animal Science And Technology Seoul National University
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Park Chan
R&d Center Kwang Dong Pharmaceutical Co. Ltd.
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LEE Yong
R&D Center, Kwang Dong Pharmaceutical Co., Ltd.
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