Sex Difference in the Relationship Between Insulin Resistance and Corrected QT Interval in Non-Diabetic Subjects

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• Background Men with a prolonged corrected QT (QTc) interval have an increased risk of cardiovascular mortality and sudden death, even in healthy individuals. In addition, prolonged QTc is a predictor of mortality in diabetics. However, the relationship between insulin resistance and QTc is not clarified in non-diabetic healthy people. The present study was performed to observe the association between QTc and insulin resistance in Korean non-diabetic subjects. Methods and Results In the current study there was a total of 874 subjects (520 men, 354 women, mean age : 45.9±11.0 years) who underwent a medical check-up at the health promotion center at Kangbuk Samsung Hospital from January 2002 to May 2002. Age, sex, height, body weight, blood pressure, blood cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), fasting insulin, and fasting glucose levels were measured. The QT intervals were corrected using Bazett's formula (QTc=QT/√<RR>). Homeostasis model assessments (HOMA) were performed to assess the correlation between insulin resistance indices and the QTc interval. The mean QTc interval was significantly longer in females (417±24 ms) than in males (402±23 ms) (p<0.001). After adjusting the variables related to the QTc interval, the differences in QTc between men and women were statistically significant (p<0.001). A significant positive correlation was found between QTc and age, glucose, and blood pressure in male subjects. Female subjects showed positive correlation between QTc and age, glucose, blood pressure, total cholesterol, low-density lipoprotein cholesterol, triglyceride, fasting insulin, and the HOMA index, and a negative correlation between QTc and HDL-C. Multiple regression analysis showed that in men, age (β=0.480, p<0.001) and diastolic blood pressure (β=0.280, p<0.001) were predictors of QTc. In women, age (β=0.321, p=0.008), diastolic blood pressure (β=0.324, p=0.006) and HOMA index (β=3.508, p=0.033) were predictors of QTc. Conclusions The present study of Korean healthy subjects shows that QTc was more prolonged in females than in males. In normoglycemic female subjects, insulin resistance was an independent determinant of the prolongation of QTc.

• 社団法人日本循環器学会の論文
• 2005-03-20

著者

• KANG JIN

  Department of Pediatrics, The Catholic University of Korea

• KIM Sun

  Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University Scho

• Kim Bum

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Kim Sun

  Department Of Chemical Engineering Sogang University

• PARK Jung

  Department of East-West Medicine, Graduate School, Kyung Hee University

• Park Jung

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Shin Hun

  Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan, University School of Medici

• Kim Byung

  Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan, University School of Medici

• Sung Ki

  Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan, University School of Medici

• Lee Man

  Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan, University School of Medici

• Rhee Eun

  Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me

• Lee Won

  Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me

• Jung Chan

  Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me

• Kirn Se

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Lee Man

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Kim Byung

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Shin Hun

  Department Of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine

• Rhee Eun

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Rhee Eun

  Department Of Computer Science Taejon National University Of Technology

• Kang Jin

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Jung Chan

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Sung Ki

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Kim Bum

  Department Of Microbiology And Cancer Research Institute Seoul National University College Of Medici

• Kim Bum

  Department Of Chemical Engineering Sungkyunkwan University

• Lee Won

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Kang Jin

  Department Of Biomedical Laboratory Science Namseoul Univeristy

• Lee Man

  Department Of Advanced Materials Science & Engineering Mokpo National University

• Jung Chan

  Department Of Chemical Engineering Hanyang University

• Kim Sun

  Department Of Internal Medicine Institute Of Medical Research Sungkyunkwan University School Of Medi

• Lee Won

  Department Of Agricultural And Biological Engineering University Of Florida

• Park Jung

  Department Of Chemistry Gyeongsang National University

• Kim Sun

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

• Kim Byung

  Department Of Applied Mathematics College Of Applied Science Kyung Hee University

• Kang Jin

  Department Of Anesthesiology And Pain Medicine Samsung Medical Center Sungkyunkwan University School

• Kim Byung

  Department Of Aerospace Engineering School Of Engineering Nagoya University

• Park Jung

  Department Electrical Engineering Busan National University

• Kim Sun

  Department Of Animal Science And Technology Seoul National University

• Sung Ki

  Department Of Cardiology Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine

• Kang Jin

  Division Of Cardiology Department Of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine

• Kim Byung

  Division Of Cardiology Department Of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine

• LEE Man

  Department of Advanced Material Science & Engineering, Mokpo National University

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