Inhibitory Effects of Saururus chinensis (LOUR.) BAILL on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice(Pharmacology)
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概要
- 論文の詳細を見る
The present study was performed to examine whether the leaves of Saururus chinensis (LOUR.) BAILL (SC), an herb used for the management of various skin diseases including atopic dermatitis (AD) in Eastern countries, inhibited the development of AD-like skin lesions in NC/Nga mice which was induced by repeated application of picryl chloride (PiCI). The efficacy of SC was judged by measurement of skin severity, itching behavior, histological study, serum IgE levels, IL-4 and IFN-γ in lymph nodes. Oral administration of SC extract to the PiCI-treated NC/Nga mice for 8 weeks (5 d per week) inhibited significantly the development of AD-like skin lesions macroscopically. Histologically, SC inhibited dermatitis changes like hypertrophy, hyperkeratosis, and infiltration of inflammatory cells into epidermis and dermis. The itching behavior and serum IgE level decreased significantly after SC administration. SC administration enhanced IFN-γ mRNA expression but did not have an effect on IL-4 mRNA expression. These results suggest that SC could inhibit the development of AD-like skin lesions in NC/Nga mice possibly through modulating the Th1/Th2 imbalance by the promoting of Th1 cell response. Thus, SC may be an alternative substance for the management of AD patients.
- 社団法人日本薬学会の論文
- 2008-01-01
著者
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CHOI Myoung
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo
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LEE Hyung
Department of Physics and Astronomy, FPRD, Seoul National University
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KIM Eui
Department of Molecular Medicine, Osaka University Graduate School of Medicine
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KIM Hyung
College of Pharmacy, Pusan National University
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KIM Sun
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University Scho
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Um Jae
College Of Oriental Medicine Institute Of Oriental Medicine Oriental Medical Science Center Kyung He
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Um Jae
韓国
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Kim Sun
Department Of Chemical Engineering Sogang University
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CHOI Hyun
Department of East-West Medicine, Graduate School, Kyung Hee University
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PARK Jung
Department of East-West Medicine, Graduate School, Kyung Hee University
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HAN Jae-Bok
Department of East-West Medicine, Graduate School, Kyung Hee University
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AN Hyo
College of Oriental Medicine, Institute of Oriental Medicine, Oriental Medical Science Center Kyung
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HAN Ah-Reum
Department of Physiology, College of Oriental Medicine, Kyung Hee University
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HONG Moo
Department of Physiology, College of Oriental Medicine, Kyung Hee University
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BAE Hyunsu
Department of Physiology, College of Oriental Medicine, Kyung Hee University
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MIN Byung-Il
Department of East-West Medicine, Graduate School, Kyung Hee University
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An Hyo
College Of Oriental Medicine Institute Of Oriental Medicine Oriental Medical Science Center Kyung He
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An Hyo
韓国
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Bae Hyunsu
韓国
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Bae Hyunsu
Department Of Physiology College Of Oriental Medicine Kyung Hee University
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Min Byung-il
Department Of East-west Medicine Graduate School Kyung Hee University
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Min Byung-il
韓国
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Han Jae-bok
Department Of East-west Medicine Graduate School Kyung Hee University
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Han Jae-bok
韓国
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Han Ah-reum
Department Of Physiology College Of Oriental Medicine Kyung Hee University
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Choi Myoung
韓国
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Choi Myoung
Department Of East-west Medicine Graduate School Kyung Hee University
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Kim Eui
Department Of Molecular Medicine Osaka University Graduate School Of Medicine
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Hong Moo
Department Of Physiology College Of Oriental Medicine Kyung Hee University
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Hong Moo
韓国
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Park Jung
Department Of East-west Medicine Graduate School Kyung Hee University
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Kim Sun
Department Of Physiology College Of Oriental Medicine Kyung Hee University
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Kim Eui
Department Of East-west Medicine Graduate School Kyung Hee University
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Kim Eui
Department Of Chemical Engineering The University Of Seoul
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Kim Hyung
College Of Oriental Medicine Institute Of Oriental Medicine Oriental Medical Science Center Kyung He
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Choi Hyun
Department Of East-west Medicine Graduate School Kyung Hee University
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Choi Hyun
Department Of Dermatology And Artificial Organ Laboratory Of The Clinical Research Institute Seoul N
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Lee Hyung
Department Of Chemistry Bk21 School Of Chemical Materials Science And Skku Advanced Institute Of Nan
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Koo Sungtae
Department Of Medical Research Korea Institute Of Oriental Medicine
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Park Jung
Department Of Chemistry Gyeongsang National University
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Kim Sun
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Park Jung
Department Electrical Engineering Busan National University
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Lee Hyung
Department Of East-west Medicine Graduate School Kyung Hee University
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Kim Sun
Department Of Animal Science And Technology Seoul National University
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Lee Hyung
Department Of Biological Sciences Konkuk University
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Bae Hyunsu
Department of Pathology, College of Oriental Medicine, Kyung Hee University
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Kim Hyung
College of Information and Communication Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Republic of Korea
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