Hypothyroidism protects di(n-butyl) phthalate-induced reproductive organs damage in Sprague-Dawley male rats
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概要
- 論文の詳細を見る
This study examined the deleterious effects of di(n-butyl) phthalate (DBP) on the male reproductive organs in hypothyroid rats. Hypothyroidism was induced in prepubertal male rats (28 days of age) by an intraperitonial (i.p.) injection of 10 mg/kg/day propylthiouracil (PTU) for 30 days. DBP (100 and 500 mg/kg/day) was administered by oral gavages to the intact or hypothyroid rats for 30 days. The body weight of the PTU-treated rats was significantly lower than the control group. The total triiodothyronine (T3) and thyroxine (T4) serum level was lower, and the thyroid-stimulating hormone (TSH) level was higher in the hypothyroid rats than in the control rats. The DBP treatment rats showed significantly lower testes, epididymides, seminal vesicles, and ventral prostate weights than the untreated rats. The hypothyroid rats had significantly higher thyroid weights and lower adrenal glands weights than the control rats. The histomorphological examination showed diffused Leydig cells hyperplasias and germ cells loss in the DBP (500 mg/kg)-treated rats, whereas these effects were mild in the DBP-treated hypothyroid rats. The serum levels of monobutyl phthalate (MBP) were significantly lower in PTU-induced hypothyroid rats than in the DBP-treated rats. This data suggests that the hypothyroid status might offer some protection from male reproductive organ toxicity caused by a disturbance in the metabolic activation of the parent compound, DBP.
- 日本トキシコロジー学会の論文
- 2008-08-01
著者
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LEE Ena
College of Pharmacy, Pusan National University
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KIM Tae
College of Pharmacy, Pusan National University
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KIM Seung
National Institute of Toxicological Research, Korea Food and Drug Administration
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LEE Jaewon
College of Pharmacy, Pusan National University
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LEE Byung
Division of Toxicology, College of Pharmacy, Sungkyunkwan University
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KIM Hyung
College of Pharmacy, Pusan National University
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Kim H
College Of Pharmacy Pusan National University
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Kim Hee
College of Pharmacy, Pusan National University
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Im Ji
College of Pharmacy, Pusan National University
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Kim Jeonga
College of Pharmacy, Pusan National University
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Park Hyeyoung
College of Pharmacy, Pusan National University
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Ryu Ju
College of Pharmacy, Pusan National University
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Shim Keun
Division of Toxicology, College of Pharmacy, Sungkyunkwan University
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Jung Kee
National Institute of Toxicological Research, Korea Food and Drug Administration
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Han Soon
National Institute of Toxicological Research, Korea Food and Drug Administration
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Han Soon
General Toxicology Team National Institute Of Toxicological Research Korea Food And Drug Administrat
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Han Soon
National Inst. Of Toxicological Res. Korea Food And Drug Administration
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Han Soon
National Institute Of Toxicological Research Korea Food And Drug Administration
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Han Soon-young
韓国
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Kim Seung
National Institute Of Toxicological Research Korea Food And Drug Administration
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Kim Hyung
College Of Oriental Medicine Institute Of Oriental Medicine Oriental Medical Science Center Kyung He
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Lee Jaewon
College Of Pharmacy Pusan National University
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Lee B
Division Of Toxicology College Of Pharmacy Sungkyunkwan University
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Jung Ki
Health Effects Analysis Team National Institute Of Food & Drug Safety Evaluation
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Kim Hee
College Of Pharmacy Pusan National University
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Im Ji
College Of Pharmacy Pusan National University
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Ryu Ju
College Of Pharmacy Pusan National University
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Jung Ki
National Institute Of Toxicological Research Korea Food And Drug Administration
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Lee Ena
College Of Pharmacy Pusan National University
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Shim Keun
Division Of Toxicology College Of Pharmacy Sungkyunkwan University
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Kim Jeonga
College Of Pharmacy Pusan National University
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Kim Seung
National Insitute Of Toxicological Research Korea Food And Drug Administration
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Park Hyeyoung
College Of Pharmacy Pusan National University
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Lee Byung
Division Of Toxicology College Of Pharmacy Sungkyunkwan University
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Kim Hyung
College of Information and Communication Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Republic of Korea
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Lee Byung
Division of Drug Discovery Research, Korea Research Institute of Chemical Technology
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