Ras Transgene Expression in TG-AC Mice Treated with Benzo[a]pyrene

概要

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Transgene expression and skin tumorigenicity were investigated in transgenic TG-AC mice carrying the v-Ha-ras after treatment with benzo|a|pyrene (BP). Animals treated with 40μg BP (×2/week/mouse) showed 100% tumor response after 25 weeks, as did 40% of the mice treated with 20μg BP but 10μg BP did not produce a tumor response. In the case of animals treated with 40μg BP for 25 weeks, most of the tumors were proven to be carcinomas (80%, 4 out of 5 mice), and all tumors were shown to be positive in terms of transgene expression detected by in situ hybridization. These data suggest that BP was tumorigenic in a dose-dependent manner in TG-AC mice and that TG-AC mice were dependent on transgene expression during BP carcinogenesis.
社団法人日本薬学会の論文
2003-05-01