Inducible Nitric Oxide Synthase mRNA Is Upregulated in Skin Tumors of v-Ha-ras Transgenic TG-AC Mice Treated with 12-o-Tetradecanoylphorbol-13-acetate
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概要
- 論文の詳細を見る
The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic α-like, ξ-globin gene. In animals treated with TPA (2.5 μg×2/week, for 2 weeks), the increase of iNOS mRNA wa locally confined only to the regions of papillomas, but not to the skin tissues surrounding the papillomas. However, the tissues surrounding the papillomas showed only a minor increase in the steady-state level of iNOS mRNA. These data suggest that iNOS gene expressions may underlie tumorigenesis during TPA promotion in TG-AC mice.
- 公益社団法人日本薬学会の論文
- 2000-07-01
著者
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LEE Byung
Division of Toxicology, College of Pharmacy, Sungkyunkwan University
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KIM Hyung
Division of Toxicology, College of Pharmacy, Sung Kyun Kwan University
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Lee B
Division Of Toxicology College Of Pharmacy Sungkyunkwan University
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Jeohn Gwang-ho
Laboratory Of Pharmacology And Chemistry National Institute Of Environmental Health Sciences Nationa
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Kim Hyung
Division Of Cardiology Department Of Internal Medicine Kyungpook National University
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Lee Byung
Division Of Toxicology College Of Pharmacy Sungkyunkwan University
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Kim Hyung
Division Of Toxicology College Of Pharmacy Sungkyunkwan University
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Kim Hyung
Division of Biotechnology, The Catholic University of Korea
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Lee Byung
Division of Drug Discovery Research, Korea Research Institute of Chemical Technology
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