Induction of apoptosis and CYP4A1 expression in Sprague-Dawley rats exposed to low doses of perfluorooctane sulfonate

スポンサーリンク

概要

• 論文の詳細を見る

• In previous studies, perfluorooctane sulfonate (PFOS), an environmental organic compound, was reported to cause hepatotoxicity and hypolipidemia in rodents. However, the low dose toxicity of PFOS and the toxic mechanisms involved remain to be determined. To clarify the low dose toxicity and action mechanism in the target organ toxicity, Sprague-Dawley (SD) rats were orally administered with PFOS at the doses of 0, 1.25, 5, 10 mg/kg/day for 28 days. As a result, no death or abnormal symptoms were observed in all groups. The significant loss of mean body weight was observed in female rats treated with 10 mg/kg PFOS and the relative liver weight of 10 mg/kg PFOS-treated group was significantly greater compared to control. Histopathological examination revealed that fatty change was evident in the liver of male rats treated with PFOS (5 and 10 mg/kg) and hypertrophy and cellular swellings in females at the dose of 10 mg/kg, which showed different pattern of pathological lesions. In addition, we demonstrated the expression induction of hepatic caspase-3 and cytochrome P450 4A1 (CYP4A1) related with apoptosis and lipid metabolism, respectively. This study suggested that no-observed-adverse-effect level (NOAEL) of PFOS was 1.25 mg/kg in 28-day repeated toxicity study and, however, the toxic response showed gender differences. The possible toxic mechanism of PFOS was the induction of apoptosis and altering lipid metabolism which resulted in hepatotoxicity.

• 2011-04-01

著者

• Kim Tae

  Health Effects Analysis Team National Inst. Of Food & Drug Safety Evaluation

• Kim Tae

  Health Effects Analysis Team National Institute Of Food & Drug Safety Evaluation

• KIM Tae

  College of Pharmacy, Pusan National University

• Kang Tae

  National Inst. Of Toxicological Res. Korea Food And Drug Administration

• Kim H

  College Of Pharmacy Pusan National University

• Han Soon

  General Toxicology Team National Institute Of Toxicological Research Korea Food And Drug Administrat

• Han Soon

  National Institute Of Toxicological Research Korea Food And Drug Administration

• Han Soon-young

  韓国

• Kim Seung

  National Institute Of Toxicological Research Korea Food And Drug Administration

• Han Soon

  Toxicological Evaluation And Research Department National Institute Of Food And Drug Safety Evaluati

• KIM Seung

  Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluat

• Kim Tae

  College Of Pharmacy Pusan National University

• Kwack Seung

  National Institute Of Toxicological Research Korea Food And Drug Administration

• Kim Seung

  Toxicological Evaluation And Research Department National Institute Of Food And Drug Safety Evaluati

• KIM Hyung-Sub

  Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluat

• KWACK Seung

  Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluat

• HAN Eui

  Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluat

• KANG Tae

  Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluat

• Kwack Seung

  Toxicological Evaluation And Research Department National Institute Of Food And Drug Safety Evaluati

• Kang Tae

  Toxicological Evaluation And Research Department National Institute Of Food And Drug Safety Evaluati

• Han Eui

  Toxicological Evaluation And Research Department National Institute Of Food And Drug Safety Evaluati

関連論文

• Effects of Postnatal Administration of Diethylstilbestrol on Puberty and Thyroid Function in Male Rats
• In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay
• Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209
• P152 Effects of Di (2-ethlyhexyl) phthalate on steroidogenesis and apoptosis in the testis of Sprague-Dawley rats
• Hypothyroidism protects di(n-butyl) phthalate-induced reproductive organs damage in Sprague-Dawley male rats
• Ras Transgene Expression in TG-AC Mice Treated with Benzo[a]pyrene
• POTENTIAL ESTROGENIC EFFECTS OF BISPHENOL : A ESTIMATED BY IN VITRO AND IN VIVO COMBINATION ASSAYS
• Association of Helicobacter pylori Infection with Gastric Adenocarcinoma
• Inhibition of Cell Growth and Induction of Apoptosis via Inactivation of NF-κB by a Sulfurcompound Isolated From Garlic in Human Colon Cancer Cells
• Effects of Di(2-ethylhexyl) Phthalate on Regulation of Steroidogenesis or Spermatogenesis in Testes of Sprague-Dawley Rats
• In vitro phototoxicity assessment of tattoo pigments using 3T3 fibroblast and reconstructed human skin model
• Integration of Micronucleus Assay into General Toxicity Testing for 3Rs
• ピレスロイド系殺虫剤にエストロゲン様活性があることをin vitro評価系を組み合わせて判定した
• Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity
• Gestational Exposure to Nonylphenol Causes Precocious Mammary Gland Development in Female Rat Offspring
• Calbindin-D_ mRNA Expression in the Rat Uterus Following Exposure to Methoxychlor : A Comparison of Oral and Subcutaneous Exposure
• Assessing Estrogenic Activity of Pyrethroid Insecticides Using In Vitro Combination Assays
• 214 Effects of Cocaine Hydrochloride on Dopaminergic System of the Brain in Rats
• Induction of apoptosis and CYP4A1 expression in Sprague-Dawley rats exposed to low doses of perfluorooctane sulfonate
• Response to Letter to the Editor
• 韓国産ジョウカイボン科の分類学的研究(6)済州島の3新種
• Evaluation of in vitro screening system for estrogenicity : comparison of stably transfected human estrogen receptor-α transcriptional activation (OECD TG455) assay and estrogen receptor (ER) binding assay

もっと見る 閉じる

スポンサーリンク