Induction of Apoptosis by Yomogin in Human Promyelocytic Leukemic HL-60 Cells(Pharmacognosy)
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概要
- 論文の詳細を見る
Yomogin is an active compound isolated from Artemisia princep, a traditional Oriental medicinal herb, which has been shown to inhibit tumor cell proliferation. In this study, we investigated the effects of yomogin on the cytotoxicity, induction of apoptosis, and putative pathways of its actions in human promyelocytic leukemia cells. Yomogin-treated HL-60 cells displayed several features of apoptosis, including DNA fragmentation, formation of DNA ladders in agarose gel electrophoresis, and externalization of annexin-V targeted phosphatidylserine residues. We observed that yomogin caused activation of caspase-8, caspase-9, and caspase-3. A general caspase inhibitor (z-VAD-fmk), caspase-8 inhibitor (z-IETD-fmk) and caspase-3 inhibitor (z-DEVD-fmk), almost completely suppressed the yomogin-induced DNA fragmentation. We further demonstrated that yomogin induced Bid cleavage, mitochondrial translocation of Bax from the cytosol, and cytochrome c release from mitochondria in a caspase-8-dependent manner. Taken together, our data indicate that yomogin is a potent inducer of apoptosis and facilitates its activity via caspase-8 activation, Bid cleavage, Bax translocation to mitochondria, and subsequent release of cytochrome c into the cytoplasm, providing a potential mechanism for the anticancer activity of yomogin.
- 社団法人日本薬学会の論文
- 2004-07-01
著者
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PARK Hee-Juhn
Division of Applied Plant Sciences, Sang-Ji University
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LEE Kyung-Tae
College of Pharmacy, Kyung-Hee University
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Ryu Shi-Yong
Korea Research Institute of Chemical Technology
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Lee Kyung-tae
韓国
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Lee Kyung-tae
College Of Pharmacy Kyung-hee University
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Lee Kyung-tae
Coll. Of Pharmacy Kyung-hee Univerisity
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Lee Kyung-tae
Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University
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Lee Kyung-tae
Coll. Of Medical Sci. Kyung Hee Univ.
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Lee Kyung-tae
Department Of Biochemistry College Of Pharmacy Kyung Hee University
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Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-juhn
韓国
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Park Hee-juhn
Dep. Of Pharmaceutical Engineering Sangji Univ.
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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Ryu Jong
Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University
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Lee Kyung
College Of Pharmacy Kyung Hee University
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Lee Kyung-won
韓国
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Lee Kyung‐won
Kyung Hee Univ. Seoul Kor
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JEONG Seoung-Hee
College of Pharmacy, Kyung Hee University
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Koo Sung-Ja
Department ofFood and Nutrition, Kyung Hee University
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HA Joo-Hun
College of Medicine, Kyung Hee University
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Ryu Jong
Department Of Oriental Pharmaceutical Science Kyunghee University
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Ryu Shi-yong
Korea Res. Inst. Of Chemical Technol.
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Park Hee-joun
Department Of Botanical Resources Sangji University
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Koo Sung-ja
Department Offood And Nutrition Kyung Hee University
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Jeong Seoung-hee
Dep. Of Pharmaceutical Biochemistry And Kyung-hee East-west Pharmaceutical Res. Inst. Coll. Of Pharm
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Leong Seoung-Hee
College of Pharmacy, Kyung Hee University
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