Taraxinic Acid, a Hydrolysate of Sesquiterpene Lactone Glycoside from the Taraxacum coreanum NAKAI, Induces the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells

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概要

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• The present work was performed to elucidate the active moiety of a sesquiterpene lactone, taraxinic acid-1'-O-β-D-glucopyranoside (1) from Taraxacum coreanum NAKAI on the cytotoxicity of various cancer cells. Based on enzymatic hydrolysis and MTT assay, the active moiety should be attributed to the aglycone taraxinic acid (la),rather than the glycoside (1). Taraxinic acid exhibited potent antiproliferative activity against human leukemia-derived HL-60. In addition, this compound was found to be a potent inducer of HL-60 cell differentiation as assessed by a nitroblue tetrazolium reduction test, esterase activity assay, phagocytic activity assay, morphology change, and expression of CD14 and CD66b surface antigens. These results suggest that taraxinic acid induces the differentiation of human leukemia cells to monocyte/macrophage lineage. Moreover, the expression level of cmyc was down-regulated during taraxinic acid-dependent HL-60 cell differentiation, whereas p21^CIPI and p27^KIPI were up-regulated. Taken together, our results suggest that taraxinic acid may have potential as a therapeutic agent in human leukemia.

• 2002-11-01

著者

• CHOI Jung-Hye

  College of Pharmacy, Kyung-Hee University

• SHIN Kyung-Min

  College of Pharmacy, Kyung-Hee University

• KIM Na-Young

  College of Pharmacy, Kyung-Hee University

• HONG Jung-Pyo

  Dentistry Kyung-Hee University

• LEE Yong

  Division of Life Sciences, Korea Institute of Science and Technology

• KIM Hyoung

  Division of Life Sciences, Korea Institute of Science and Technology

• PARK Hee-Juhn

  Division of Applied Plant Sciences, Sang-Ji University

• LEE Kyung-Tae

  College of Pharmacy, Kyung-Hee University

• Choi Jongwon

  Coll. Of Pharmacy Kyungsung Univ.

• Choi Jong-won

  韓国

• Choi Jong-won

  College Of Pharmacy Kyung-sung University

• Lee Kyung-tae

  韓国

• Lee Kyung-tae

  College Of Pharmacy Kyung-hee University

• Lee Kyung-tae

  Coll. Of Pharmacy Kyung-hee Univerisity

• Lee Kyung-tae

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• Lee Kyung-tae

  Coll. Of Medical Sci. Kyung Hee Univ.

• Lee Kyung-tae

  Department Of Biochemistry College Of Pharmacy Kyung Hee University

• Park Hee-juhn

  Department Of Pharmaceutical Engineering Sangji University

• Park Hee-juhn

  韓国

• Park Hee-juhn

  Division Of Applied Plant Sciences Sangji University

• Park Hee-juhn

  Department Of Botanical Resources Sangi University

• Ryu Jong

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• Shin Kyung-min

  College Of Pharmacy Kyung-hee University

• Shin Kyung-min

  韓国

• Kim N‐y

  College Of Pharmacy Kyung-hee University

• Lee Kyung

  College Of Pharmacy Kyung Hee University

• Lee Kyung-won

  韓国

• Lee Kyung‐won

  Kyung Hee Univ. Seoul Kor

• Shin Kyung-min

  Toxicology Department National Institute Of Toxicological Research Korea Food And Drug Administratio

• Kim Hyoung

  Bioanalysis And Biotransformation Res. Center Life Sciences Res. Div. Korea Inst. Of Sci. And Techno

• Ryu Jong

  Department Of Oriental Pharmaceutical Science Kyunghee University

• Choi Jong-won

  Coll. Of Pharmacy Kyungsung Univ.

• Lee Y

  Dep. Of Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.

• Choi Jung-hye

  Department Of Internal Medicine Hanyang University

• Park Hee-joun

  Department Of Botanical Resources Sangji University

• Kim Na-young

  College Of Pharmacy Kyung-hee University

• Choi Jung-hye

  Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.

• Lee Yong

  Division Of Applied Life Science Graduate School Gyeongsang National University

• Choi Jeongeun

  College Of Pharmacy Kyungsung University

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